Preparation method and application of flavone-C-glycoside 6'' hydroxyl-ester derivative

A technology of flavonoid carbon glycosides and ester derivatives, which is applied in food preparation, skin care preparations, medical preparations containing active ingredients, etc., can solve the problem of enzymatic conversion of few natural products, and achieve high specificity, The effect of mild reaction conditions and easy purification
CN103045674AInactive Publication Date: 2013-04-17NANJING NUOYUN BIOLOGICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING NUOYUN BIOLOGICAL TECH CO LTD
Publication Date
2013-04-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a preparation method of a flavone-C-glycoside 6'' hydroxyl-ester derivative. By taking a flavone-C-glycoside 6'' hydroxyl extract having wide source and low activity as a substrate, the method enables esterification reaction between the substrate and carboxylic acid in the presence of microorganism lipase and organic solvent so as to obtain a flavone-C-glycoside 6'' hydroxyl-ester derivative rarely seen in nature and having high activity through local specific synthesis. In the reaction process, monitoring is performed by a detection method of thin-layer chromatography or efficient liquid chromatography until all start raw materials are consumed; and after the reaction, lipase is filtered, and the esterified product is washed and purified by the organic solvent. The method has the advantages of easily available substrate, simple preparation technology, high specificity and mild reaction conditions; the obtained product is easy to purify; and sufficient raw material guarantee is provided to the application of flavone-C-glycoside 6'' hydroxyl-ester derivative in the fields of functional food, beverage, cosmetics, medicine and the like.
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Description

technical field

[0001] The invention relates to a preparation method of flavonoid carbon glycoside 6"hydroxyl-ester derivatives, belonging to the technical field of activity modification of flavonoid compounds. Background technique

[0002] Enzyme-catalyzed reaction conditions are mild, organic solvent consumption is small, energy consumption is low, and environmental pollution is minimal. More importantly, the enzymatic conversion reaction has high regio- and stereoselectivity, excellent yield and purity (especially enantiomeric excess and ee value). According to these advantages, under suitable conditions, enzyme-catalyzed technology has been widely used in the industrial production process of many food, beverage and pharmaceutical materials, especially in the preparation of drugs and chiral intermediates. However, enzymatic transformations are rarely used to modify and optimize the activity of natural products.

[0003] Flavonoids are widely found in vegetables, fruits,...

Claims

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