Method for comprehensively detecting active ingredients of Longdan Xiegan particles

A technology of gentian purging the liver and detection method, which is applied in the directions of measuring device, material separation, and analysis of materials, etc., can solve the problems of incomplete content determination and cannot comprehensively reflect the content of gentian purging liver granules, etc., so as to increase inspection and reduce toxic side effects

Inactive Publication Date: 2013-04-24
JILIN ZIXIN PHARMA
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Problems solved by technology

[0010] The present invention provides a method for detecting the active ingredients of Lo...

Method used

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Embodiment Construction

[0045] Longdan Xiegan Granules are produced and provided by Jilin Zixin Pharmaceutical Co., Ltd. according to the prescription and process in the background technology.

[0046] Including the following identification methods, content determination methods and inspection methods:

[0047] (1) Identification method

[0048] (1) Take 12g of Longdan Xiegan Granules of this product, add 30ml of water, heat to dissolve, let cool, extract 3 times with ether, 15ml each time, discard the ether solution, and then extract 3 times with n-butanol saturated with water, 15ml each time, combine the n-butanol solution, add an equal volume of ammonia test solution, shake well, put it into layers, separate the supernatant, recover n-butanol under reduced pressure until dry, add 1ml methanol to the residue to dissolve, and use it as the test sample solution; take another geniposide reference substance, add methanol to make a solution containing 1mg per 1ml, and use it as the reference substance ...

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Abstract

The invention relates to a method for detecting active ingredients of Longdan Xiegan particles and belongs to the field of modernization of Chinese traditional medicine. According to the invention, the method for detecting the Longdan Xiegan particles is standardized; on the basis of original identification on gardenia, by establishment of identification and content determination on gentian, identification and content determination on baical skullcap root and liquorice and content determination on gardenia serving as ministerial drug, ingredients of the medicament and compatibility of the ingredients can be more comprehensively detected and content and stability of the Longdan Xiegan particles can be more comprehensively known; the method is also helpful to explaining the medicinal material basis of the medicament; and meanwhile, due to increase of examination on aristolochic acid, the method is more beneficial for reducing toxic and side effects of the Longdan Xiegan particles.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine modernization, and in particular relates to a detection method of Longdan Xiegan Granules. Background technique [0002] The composition of traditional Chinese medicine is complex, especially the compound prescription of traditional Chinese medicine often contains many kinds and many kinds of ingredients, forming a very complicated system. At present, the research and development of new effective parts of traditional Chinese medicine preparations and modern compound Chinese medicine preparations are increasing, and new processes and various extraction methods are used in the research and production of medicines. [0003] With the rapid development of modern analysis and testing technology, equipment and instruments, the content determination and chromatographic identification of traditional Chinese medicine have become important means of detection. However, at present, only the content...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/02
Inventor 殷金龙高艳辉李坤徐德辉马伟才杨锡龙李男男樊艳霞李雪宁超群
Owner JILIN ZIXIN PHARMA
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