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Application of Roseburia to treatment and prevention of obesity related disease

A Rothella, the use of technology, applied in the field of microbiology, can solve the problems of immune resistance, calculation errors, small side effects, treatment and prevention of obesity and its related diseases

Active Publication Date: 2013-05-08
SHENZHEN HUADA GENE INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For patients, the use of exogenous insulin is an expensive and painful method, and it also brings many complications to the patient
Insulin response (hypoglycemia) due to miscalculation of insulin doses, for example, due to missing meals or erratic exercise
In addition, local or systemic allergy or immune resistance to the drug may occur with the use of the drug
[0006] At present, there is no effective method and medicine for the treatment and prevention of obesity and related diseases with little side effects in this field, so there is an urgent need in this field to develop a new, non-toxic and side effect drug for the treatment and prevention of obesity and obesity. Drugs for its related diseases

Method used

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  • Application of Roseburia to treatment and prevention of obesity related disease
  • Application of Roseburia to treatment and prevention of obesity related disease
  • Application of Roseburia to treatment and prevention of obesity related disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Experimental Materials

[0069] Mice: C57BL / 6J mice (purchased from the Experimental Animal Center of Southern Medical University) were purchased, which were 6-week-old normally bred mice, 15 in total. Mice were raised in the same environment and fed the same food.

[0070] Strain: Roseburia inulinivorans DSM 16841 strain, purchased from DSMZ (Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH).

[0071] High-fat food (HF): containing 58% lard, 25.6% carbohydrate, and 16.4% protein, purchased from Beijing Huafukang Biotechnology Co., Ltd.

[0072] Conventional mouse food: purchased from the Animal Experiment Center of Southern Medical University.

Embodiment 2

[0074] Grouping and induction of mice

[0075] In this embodiment, 3 experimental groups were set up, with 5 animals in each group.

[0076] 6-week-old C57BL / 6J mice fed normally (no need to be sterile) were selected for the experiment. The DSM 16841 bacteria to be tested were introduced into the intestinal tract of the mice by feeding method, and the insulin resistance ability of the mice was identified by the glucose tolerance (OGGT) test.

[0077] For specific experimental grouping information and processing steps, see figure 1 .

[0078] The 15 repurchased mice were kept in the same environment until they were 6 weeks old (the food did not need to be sterilized), the amount of food fed was recorded, and the body weight and physical condition of the mice were regularly monitored.

[0079] The 15 mice were equally divided into 3 experimental groups (5 replicates in each experimental group), placed in ultra-clean workbenches, and formally entered the experimental period. Th...

Embodiment 4

[0084] Experimental results:

[0085] 1. The body weight gain results of feeding mice for 10 weeks are shown in Table 1 and figure 2 .

[0086] Table 1

[0087]

[0088] 2. The comparison results of the P value of the difference in body weight growth of mice fed for 10 weeks are shown in Table 2 and image 3 .

[0089] Table 2

[0090]

[0091] From Table 1, Table 2 and figure 2 , image 3 It can be seen that feeding the test bacteria can significantly reduce the body weight of obese mice after feeding for 10 weeks.

[0092] 3. See Table 3, Table 4 and Figure 4 , Figure 5 .

[0093] table 3

[0094] group

[0095] 1.

[0096] Table 3 and Figure 4 It was shown that feeding the test bacteria can significantly reduce the blood sugar of obese mice.

[0097] Table 4

[0098] P value

[0099] Table 4 and Figure 5 It was shown that feeding the test bacteria can significantly improve the blood sugar tolerance of obese mice.

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Abstract

The invention provides application of Roseburia to treatment and prevention of obesity related disease. The invention provides the application of Roseburia to the treatment and prevention of obesity related diseases, and a composition for treatment and prevention of obesity related diseases, wherein the composition comprises drug, drink, food, or animal feed composition; besides, a method for reducing the weight and / or blood sugar is also provided.

Description

technical field [0001] The invention belongs to the field of microbiology. Specifically, the invention relates to the application of Roseburia in the treatment and prevention of obesity-related diseases, and also relates to a composition containing Roseburia and its application. Background technique [0002] Obesity is a chronic disease, many factors can lead to obesity, its origin has not been studied clearly. Obesity is also an inducing factor for a series of diseases, such as hypertension, diabetes, coronary heart disease, gallbladder disease, osteoarthritis, sleep apnea, respiratory disorders, uterine tumors, prostate cancer, breast cancer and colon cancer. According to the NHI report, currently about 97 million Americans are overweight and obese, of which about 15.1 million are type 2 diabetes related to obesity, and about 200,000 people die from obesity-related diseases every year. [0003] Obesity is usually excess body fat due to altered physiological or biochemical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30A23L2/52A23K1/16A61K35/74A61P3/04A61P3/10
CPCA23L1/3014A61K35/74C12R1/01A61K9/19A23L33/135A61P3/04A61P3/10C12N1/20Y02A50/30A23V2002/00
Inventor 覃俊杰李胜辉朱剑锋李晓平梁穗莎王俊汪建杨焕明
Owner SHENZHEN HUADA GENE INST
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