Bromadiolone mother liquid preparation method

Abstract

The invention discloses a bromadiolone mother liquid preparation method which comprises the following steps of: mixing alcohol and boiler refluxing cooling water or de-ionized water which are equal in weight, adding a certain amount of 10% bromadiolone and mixing under an alkaline condition. The method disclosed by the invention is simple and convenient, capable of remarkably reducing production cost of products and is strong in practicability; the prepared product is stable in quality, and environment-friendly and free from pollution in the production process; the preparation method, compared with a conventional bromadiolone preparation method, can nearly reduce half of cost, and is free from influence on palatability of rats and free from generation of foams; the prepared product is clear, transparent and stable in quality; freezing point of the bromadiolone rat poison produced by the preparation method is about minus 42 DEG C, which can avoid freezing generally in most regions, so that not only is a great amount of alcohol saved but also production cost is reduced.

Description

technical field [0001] The invention relates to a preparation method of a novel high-efficiency and low-toxic rodenticide. Background technique [0002] Bromadiolone is a highly effective and low-toxic rodenticide, the chemical name is 3-[3-(4-bromobiphenyl-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxycoumarin , the chemical molecular formula is: C30H23BrO4. The solubility of bromadiolone in water is about 19 mg per liter, while the solubility in ethanol is 8200 mg per liter, so various rat poison manufacturers generally dissolve bromadiolone in alcohol solution to make 0.5% Bromadiolone alcohol mother liquor, formula is as follows: 950 kilograms of alcohol, 50 kilograms of 10% bromadiolone. There are also some manufacturers, in order to save costs, use 30-40% alcohol aqueous solution plus 15% microemulsion to make 0.5% bromadiolone master drug. The formula is as follows: 350 kg of alcohol, 635 kg of tap water, 15 kg of microemulsion, and 50 kg of 10% bromadiolone. The above...

AI Technical Summary

Problems solved by technology

The above two bromadiolone formulas all have disadvantages: the first formula, in order to allow bromadiolone to be completely dissolved into a transparent and clear bromadiolone solution, and to make the parent drug have better palatability to mice, its solvents are all Edible alcohol, its disadvantage is: higher cost, and waste a lot of alcohol (currently 6250 yuan per ton of alcohol); the disadvantage of the second formula is: because the solubility of bromadiolone in water is too small, in order to make bromadiolone completely Dissolved in 30-40% alcohol aqueous solution, need to add about 15% emulsifier, that is, surfactant, the addition of these emulsifiers will firstly make the prepared bromadiolone solution produce a lot of foam during operation , affect the operation of the machine, and the senses are not good; secondly, because the sense of smell of mice is particularly sensitive (the sense of smell of mice is 10 times that of dogs), the addition of these microemulsions affects the palatability of the mother drug to mice to a certain extent, making The rodent control effect is reduced; moreover, because the price of microemulsion is relatively expensive, 18-20 yuan per kilogram, so the production cost is increased, and the freezing point of this formula is relatively high, and it will freeze at minus 10 degrees, so the current formula technology Few manufacturers use