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Calcium borogluconate solution and preparation method thereof

A technology of calcium borogluconate and calcium gluconate, which is applied in the field of calcium borogluconate solution and its preparation, can solve the problems of easily causing hypercalcemia and difficulty in controlling the amount of clinical calcium, so as to inhibit the precipitation of calcium and be suitable for large-scale Large-scale production application, the effect of improving stability

Active Publication Date: 2013-07-10
ZHENGZHOU BARY ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, compared with oral preparations, intravenous injection also has the problem that clinical calcium content is more difficult to control, and it is easy to cause hypercalcemia

Method used

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  • Calcium borogluconate solution and preparation method thereof
  • Calcium borogluconate solution and preparation method thereof
  • Calcium borogluconate solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The calcium borogluconate solution in this example is composed of the following components: 10 g of boric acid, 100 g of calcium gluconate, 0.2 g of paraben, 0.2 mL of orange flavor, and 300 mL of purified water. The specific preparation method is:

[0024] (1) Accurately take each component, first add 50% purified water into the liquid mixing tank, heat up to 80°C, add boric acid, calcium gluconate, paraben and sweet orange flavor in sequence, and stir while adding , when the boric acid, calcium gluconate, paraben and sweet orange essence are completely dissolved, continue to heat, seal and boil to dissolve for 30 minutes, then stop heating;

[0025] (2) Add 0.1g of activated carbon to the solution in step (1) and stir evenly. After airtight adsorption for 30 minutes, turn on the circulating cooling water to cool to 50°C, then adjust the pH value of the solution to 5.5, add purified water to the full amount, and filter. Fill the filtrate and get it.

Embodiment 2

[0027] The calcium borogluconate solution in this example is composed of the following components: 20 g of boric acid, 138 g of calcium gluconate, 0.25 g of paraben, 0.5 mL of sweet orange flavor, and 350 mL of purified water. The specific preparation method is:

[0028] (1) Accurately take each component, first add 70% of purified water into the liquid mixing tank, heat up to 60°C, add boric acid, calcium gluconate, paraben and sweet orange fragrance in turn, and stir while adding , until the boric acid, calcium gluconate, paraben and sweet orange essence are completely dissolved, continue to heat, seal and boil for 40 minutes to dissolve, then stop heating;

[0029] (2) Add 0.1g of activated carbon to the solution in step (1) and stir evenly. After airtight adsorption for 20 minutes, turn on the circulating cooling water to cool to 40°C, then adjust the pH of the solution to 5.8, add purified water to the full amount, and filter. Fill the filtrate and get it.

Embodiment 3

[0031] The calcium borogluconate solution in this example is composed of the following components: 25 g of boric acid, 140 g of calcium gluconate, 0.5 g of paraben, 0.5 mL of sweet orange flavor, and 350 mL of purified water. The specific preparation method is:

[0032] (1) Accurately take each component, first add 60% purified water into the liquid mixing tank, heat up to 100°C, add boric acid, calcium gluconate, paraben and sweet orange flavor in sequence, and stir while adding , until the boric acid, calcium gluconate, paraben and sweet orange essence are completely dissolved, continue to heat, seal and boil for 20 minutes to dissolve, then stop heating;

[0033] (2) Add 0.2g of activated carbon to the solution in step (1) and stir evenly. After airtight adsorption for 40 minutes, turn on the circulating cooling water to cool to 45°C, then adjust the pH value of the solution to 5.5, add purified water to the full amount, and filter. Fill the filtrate and get it.

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Abstract

The invention discloses a calcium borogluconate solution and a preparation method thereof, and belongs to the technical field of veterinary drugs. The solution consists of the following components by content: 10-25g of boric acid, 100-150g of calcium gluconate, 0.2-0.5g of paraben, 0.2-0.8mL of edible essence, 200-350mL of purified water. The solution has the advantages of high calcium content, strong stability, difficulty in separation and the like. Boric acid has a function of promoting calcium gluconate to dissolve; and paraben is also called as p-hydroxybenzoate, has a strong bacteriostatic function when the pH value is 3-8 and cooperates with boric acid so as to promote calcium gluconate to dissolve, so that the stability of the calcium borogluconate solution is obviously improved. A sealed boiling dissolving method is adopted to promote boric acid and calcium gluconate to be fully combined with each other, so that the dissolubility of calcium gluconate is improved, and the calcium content of the solution is increased; and furthermore, the stability of a dissolving agent is enhanced, and calcium in a finished product is inhibited from separating out.

Description

technical field [0001] The invention relates to a calcium borogluconate solution and a preparation method thereof, belonging to the technical field of veterinary medicines. Background technique [0002] The metabolic balance of calcium in livestock is mainly achieved through two pathways: intake of calcium from feed and excretion of calcium from the body, so as to maintain the stability of calcium concentration in plasma. Once the balance is broken, it will lead to too high or too low calcium concentration in blood plasma, which can easily cause diseases such as bone fibrodystrophy. In my country, livestock diseases caused by calcium deficiency have seriously affected animal husbandry. Therefore, in addition to feed, the source of calcium in livestock also includes calcium supplements, which are mainly used to prevent and treat calcium spasm (calcium convulsions), postpartum paralysis, osteomalacia, rickets, osteoporosis and other diseases in livestock. [0003] At present...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/04A61K47/14A61K31/191A61P3/02
CPCY02A40/70
Inventor 郭玉凡王佳伟杨晶张宁张旭
Owner ZHENGZHOU BARY ANIMAL PHARMA
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