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Diarrhoea-stopping traditional Chinese medicine composition, capsule and application thereof

A technology of capsules and traditional Chinese medicines, applied in the directions of drug combination, capsule delivery, non-central analgesics, etc., to achieve the effect of significant technological progress

Active Publication Date: 2013-07-10
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the anti-colitis effect of amaranth has been recorded, there are very few related reports in China

Method used

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  • Diarrhoea-stopping traditional Chinese medicine composition, capsule and application thereof
  • Diarrhoea-stopping traditional Chinese medicine composition, capsule and application thereof
  • Diarrhoea-stopping traditional Chinese medicine composition, capsule and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The active investigation of the extract of different medicinal materials and combinations of embodiment 1

[0018] Weigh 200g of chopped amaranth medicinal material, put it into a 3L flask, add 70% ethanol and reflux extraction 3 times (9, 7, 7 times the amount of raw medicinal material), reflux extraction for 3 hours each time, cool slightly (30-40°C) , filter, remove dregs to obtain brown filtrate 420ml, reclaim ethanol under reduced pressure, obtain thick extract weight 36.40g, yield 18.20%, obtain the iron amaranth group.

[0019] Weigh 200g of chopped purslane medicinal material, put it into a 3L flask, add 70% ethanol to reflux and extract 3 times (8, 6, 6 times the amount of raw medicinal material), each time for 3 hours, slightly cool (30-40°C) , filter, remove the dregs, get dark brown filtrate 420ml, reclaim ethanol under reduced pressure, get thick extract weight 53.72g, yield 26.86%, get purslane group.

[0020] Weigh 200g of diarrhea-stopping medicinal mat...

Embodiment 5

[0031] Example 5 Water, different concentrations of ethanol extracts on the impact of Xie Ting traditional Chinese medicine combination activity

[0032] Weigh the medicinal materials according to the diarrhea-stopping medicinal materials (Amaranth: Purslane = 7:3), and perform the following operations respectively;

[0033] Boiled extract: Boil 300g of raw medicinal materials in water, the amount of water is 8 times the weight of medicinal materials, the dry matter weight is 61.5g, and the extraction rate is 20.5%.

[0034] 70% ethanol extraction: extract 500g of crude drug with 70% ethanol, the amount of ethanol is 5 times of the weight of the medicinal material, and extract once, the dry matter weight is 98.5g, and the extraction rate is 14.7%.

[0035] 80% ethanol extraction: extract 300g of crude drug with 80% ethanol, the amount of ethanol is 5 times of the weight of the medicinal material, and extract once, the dry matter weight is 35.20g, and the extraction rate is 11....

Embodiment 3

[0041] Example 3 Boiled and alcohol-precipitated samples are investigated for the influence of diarrhea Ting traditional Chinese medicine combination activity

[0042] Take 200g of diarrhea-stopping herbs (Amaranth: Purslane = 7:3) into an enamel pot, add normal water and boil 3 times (14 times the amount of water for the first time, cook for 2 hours, the second time 8 times the amount of water, boil 1.5 hours, 8 times the amount of water for the third time, boil for 1 hour), filter, collect the filtrate in a water bath at 70-80°C, concentrate appropriately, add ethanol for precipitation (the ethanol concentration reaches 70%), room temperature (12-16°C) Leave to stand for 24 hours, filter to obtain precipitate and filtrate, ethanol is recovered from the filtrate under reduced pressure, and an extract No. 1 is obtained as sample 1, weighing 19g, and the yield is 9.5%, and the precipitate weighs 43.62g, and the yield is 21.81%.

[0043]Get about 40 Kunming mice of about 20g of ...

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Abstract

The invention discloses a diarrhea-stopping traditional Chinese medicine composition, a capsule and application thereof, and provides a drug composition of acalypha australis and herba portulacae. Found in the search disclosed by the invention, an extract which is prepared from a drug composition formula of acalypha australis and herba portulacae by aqueous extraction and alcohol extraction, and various products purified from alcohol extract have activity on diarrhea. Compared with the traditional water extract technology, the extract and the prepared capsule preparation obtained by the scheme, and the product purified by the technology have significant technical progress and material distinguishing technical characteristics.

Description

technical field [0001] The invention relates to a medicine, in particular to a combination of traditional Chinese medicine for diarrhea and anti-diarrhea, capsules and applications thereof. technical background [0002] Diarrhea is not an independent disease, but a common manifestation of many diseases. It can also be accompanied by vomiting, fever, abdominal pain, abdominal distension, mucus stool, bloody stool and other symptoms. [0003] Purslane is a plant of the family Portulaca oleracea. It is a traditional Chinese medicine in my country. It has the effects of dispersing blood, reducing swelling, clearing away heat and detoxifying. "Reputation. The whole plant of purslane is rich in adrenaline, flavonoids, cardiac glycosides and other substances, which have good anti-inflammatory, anti-tumor, and cardiovascular disease-reducing effects. [0004] The flavonoids in purslane can significantly inhibit the paw edema induced by carrageenan in rats. Therefore, we speculate t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61K9/48A61P1/12A61P1/00A61P29/02A61P31/04A61K36/185
Inventor 张小梅唐耀书周远鹏梁旭明杨大坚
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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