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Application of pinitol to pharmacy and health care product

A health care product, pine alcohol technology, applied in application, ether/aldehyde active ingredients, food preparation, etc., can solve problems such as lack of cognition and narrow application range, achieve rich sources, reduce plasma lipids, and reduce plasma The effect of triglycerides

Inactive Publication Date: 2013-07-17
SHAANXI HUAXIN ECONOMIC & TRADE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the lack of awareness of this product, the current application range is narrow

Method used

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  • Application of pinitol to pharmacy and health care product
  • Application of pinitol to pharmacy and health care product
  • Application of pinitol to pharmacy and health care product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] This example shows that when people with type 2 non-insulin-dependent diabetes ingest pinitol fractions extracted from soybeans, the plasma levels of pinitol and D-chiro-inositol will increase, and the plasma insulin and blood sugar levels will decrease.

[0039] Five non-insulin-dependent diabetic subjects were studied under two conditions every other week. For three consecutive days, the patient took pinitol 4.15mg / kg / day orally. The preparation also contains 0.85 mg / kg / day of other forms of D-chiro-inositol. The total content of inositol (including pinitol) is 22.5% by weight. On the morning of the fourth day, they did not take hypoglycemic drugs and reported to the Clinical Research Center. Baseline blood samples were taken at -90 and -60 typing, and pinitol was orally administered at -60 typing, with the same amount as the previous three days. Materials contain less than 5 calories. Glucose tolerance testing was initiated at time zero using 75 g of blood glucos...

Embodiment 2

[0047] This example demonstrates that plasma D-chiroinositol is strongly associated with plasma triglycerides and HDL in diabetic subjects.

[0048] Nineteen insulin-dependent diabetic subjects and fifty-four non-insulin-dependent diabetic subjects were studied during the analysis of factors influencing plasma triglyceride and high-density lipoprotein levels by cruciform cut-off. Age, sex, body mass index, concomitant drug therapy, glycosylated hemoglobin, and plasma lipids are well known covariates affecting plasma insulin and lipoproteins, which were measured in the present invention. Plasma D-chiroinositol was measured and its values ​​were used in multiple regression equations to predict plasma triglycerides and high-density lipoprotein cholesterol. Through the research, we found the statistical correlation in Table 2 below:

[0049] Table 2 Relationship between plasma D-chiro-inositol and plasma triglyceride and high-density lipoprotein in diabetic subjects

[0050]

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Abstract

The invention provides application of pinitol to pharmacy and health care product. Compared with the prior art, the invention has the beneficial effects that: novel medical application and health care application of a known compound is explored, and a new application field is developed; the product has rich source and simple preparation process, can be prepared into an oral preparation, an injection and tablet, and is convenient for use; the configured drug product or health care product has effects of increasing plasma levels of pinitol and D-chiro-inositol, and decreasing plasma insulin and glucose levels; and the configured drug product or health care product has effects of reducing the blood sugar value, insulin level, plasma lipid and plasma triglyceride.

Description

technical field [0001] The invention relates to the use of pinitol substances in medicine or health products. Background technique [0002] Pinitol is a known compound with the formula C 7 h 14 o 6 , its molecular weight is 194.18, its CAS number is 10284-63-6, and its melting point is 178-185°C. The prior art shows that the combination of pinitol and creatine products can promote the absorption of creatine so as to accelerate the growth of muscles, and is applied in the field of body building and muscle gain. Due to the lack of awareness of this product, the scope of application is now narrow. Contents of the invention [0003] The present invention proposes the application of pinitol in the preparation of drugs and / or health care products for the prevention and / or treatment of insulin resistance diseases, that is, the new application in pharmacy or preparation of health care products. [0004] In fact, the present invention relates to the application of pinitol subs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/075A61K31/047A61P3/10A61P3/04A61P3/06A61P9/10A61P9/12A61P9/00A61P31/18A61P35/00A61P31/06A61P37/00A61P17/02A61P3/02A61P5/00A61P19/06A61P15/00A23L1/30
Inventor 王燕金
Owner SHAANXI HUAXIN ECONOMIC & TRADE
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