Novel slow-release breast perfusion agent for preventing cow subclinical mastitis and preparation method thereof

The technology of subclinical mastitis and perfusion agent is applied in the field of slow-release breast perfusion agent for preventing subclinical mastitis in dairy cows and its preparation field, which can solve the problems of hidden danger of food safety, economic loss, increase of white blood cell content and the like, and achieves reduction of drug administration frequency, good stability, and the effect of preventing recessive mastitis in dairy cows

Active Publication Date: 2013-08-07
中国牧工商集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to changes in the physical and chemical properties of the milk secreted by sick cows with mastitis, increased white blood cell content, and pathological changes in the mamm

Method used

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  • Novel slow-release breast perfusion agent for preventing cow subclinical mastitis and preparation method thereof
  • Novel slow-release breast perfusion agent for preventing cow subclinical mastitis and preparation method thereof
  • Novel slow-release breast perfusion agent for preventing cow subclinical mastitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Sustained-release udder perfusion agent for preventing latent mastitis in dairy cows and its preparation

[0016] The composition of each 100g perfusion agent is as follows:

[0017]

[0018]

[0019] Crush benzathine cefapirin bulk drug until more than 90% of the particle diameter reaches 3-5 μm, and the sterilization meets the aseptic requirements, which is material A; sterilize the soybean oil for injection (sterilize by filtering with a sterile filter membrane), add Polyethylene glycol-400 (PEG-400), fatty alcohol polyoxyethylene ether (AEO-7), stir and mix, continue to heat for 5 hours, cool down to room temperature, it is liquid B; material A, liquid B, vitamin E , Benzyl alcohol is fed into a high-pressure homogenizer, and the high-pressure homogenizer is used to circulate and homogenize for 7 minutes. The pressure is controlled at 50Mpa, and the quantification is up to 100g. Packing, sealing, and packaging.

Embodiment 2

[0020] Example 2 Sustained-release udder perfusion agent for preventing latent mastitis in dairy cows and its preparation

[0021] The composition of each 100g perfusion agent is as follows:

[0022]

[0023] Crush benzathine cefapirin raw material until more than 95% of the particle diameter reaches 3-5 μm, and the sterilization meets the aseptic requirements, which is material A; sterilize the soybean oil for injection (sterilize by filtering with a sterile filter membrane), add Polyethylene glycol-400 (PEG-400), fatty alcohol polyoxyethylene ether (AEO-7), stir and mix, continue to heat for 4 hours, cool down to room temperature, and it is liquid B; material A, liquid B, vitamin E , Benzyl alcohol is fed into a high-pressure homogenizer, and the high-pressure homogenizer is used to circulate and homogenize for 5 minutes, the pressure is controlled at 150Mpa, and the quantification is up to 100g, and then packed, sealed, and packaged.

Embodiment 3

[0024] Example 3 Sustained-release udder perfusion agent for preventing latent mastitis in dairy cows and its preparation

[0025] The composition of each 100g perfusion agent is as follows:

[0026]

[0027]

[0028] Grind benzathine cefapirin bulk drug until more than 90% of the particle diameter reaches 3-5 μm, and sterilize to meet the sterile requirements, which is material A; sterilize the liquid paraffin (sterilize by filtering with a sterile filter membrane), add Tween -80, cyclomethylene glyceryl ether, stir and mix, continue to heat for 5 hours, drop to room temperature, and become liquid B; feed material A, liquid B, vitamin E, and benzyl alcohol into a high-pressure homogenizer, and use high-pressure homogenization The machine circulates homogeneously for 10 minutes, the pressure is controlled at 100Mpa, the quantitative is 100g, subpackaged, sealed and packaged.

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Abstract

The invention provides a novel slow-release breast perfusion agent for preventing cow subclinical mastitis and a preparation method thereof. 100g of the novel slow-release breast perfusion agent comprises 1 to 5g of cephapirin benzathine, 0.5 to 8g of polyethylene glycol-400, Tween materials or propylene glycol, 0.5 to 8g of fatty alcohol-polyoxyethylene ether, cyclomethylene glyceryl ether, glyceryl triacetate or poloxamer, 0.02 to 0.05g of vitamin E, 0.05 to 0.1g of benzyl alcohol, and the balance soybean oil for injection, liquid paraffin or median-chain triglyceride. The invention also provides a preparation method of the novel slow-release breast perfusion agent. The novel slow-release breast perfusion agent is suspended colloid, can be released slowly, has low administration frequency, can prevent cow subclinical mastitis in a mild shortage stage, and does not produce residues in milk in a lactation stage. Compared with foreign like products, the suspended colloid has better stability.

Description

technical field [0001] The invention relates to the field of veterinary drug preparation, in particular to a slow-release udder perfusion agent for preventing latent mastitis in cows and a preparation method thereof. Background technique [0002] Dairy cow mastitis is one of the diseases that cause the most serious economic loss in dairy farms, especially dairy cow recessive mastitis, which is still one of the important diseases that endanger the dairy industry in the world because it has no obvious clinical symptoms and is easy to be ignored. Due to changes in the physical and chemical properties of the milk secreted by sick cows with mastitis, increased white blood cell content, and pathological changes in mammary gland tissue, it not only causes serious economic losses to the dairy farming and dairy processing industries, but also brings certain risks to food safety. hidden dangers. [0003] Sustained-release preparations mean that by delaying the release rate of the dru...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61K9/06A61P15/14
Inventor 宋敏何继红吴家鑫葛辛玫巴利民张刚张传良张淼赵梅仙齐鹏郑应华
Owner 中国牧工商集团有限公司
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