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Tooth surface adhesion inhibitor of periodontal pathogenic bacteria, oral biofilm formation inhibitor, and composition for oral cavity

A biofilm and inhibitor technology, which is applied in drug combination, skin care preparations, oral care, etc., can solve the problems of insufficient biofilm bactericidal effect, achieve good inhibitory effect, improve and prevent periodontal disease, and improve biological The effect of membrane bactericidal effect

Active Publication Date: 2016-01-20
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, Patent Document 1 discloses that when propylene glycol alginate and triclosan are used in combination, the bactericidal effect on biofilm is not sufficient, and there is room for improvement.

Method used

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  • Tooth surface adhesion inhibitor of periodontal pathogenic bacteria, oral biofilm formation inhibitor, and composition for oral cavity
  • Tooth surface adhesion inhibitor of periodontal pathogenic bacteria, oral biofilm formation inhibitor, and composition for oral cavity
  • Tooth surface adhesion inhibitor of periodontal pathogenic bacteria, oral biofilm formation inhibitor, and composition for oral cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] Adhesion inhibition effect of periodontal pathogenic bacteria

[0114] The adhesion inhibitory effect of periodontal pathogenic bacteria was evaluated by the following method with respect to the test composition whose composition is shown in Table 1. The results are shown in Table 1.

[0115] The periodontal pathogenic bacterial strain used in the determination is the Porphyromonas gingivalis (Porphyromonas gingivalis) ATCC33277 bacterial strain purchased from the American Culture Collection (ATCC), and it is put into Todd Hugh containing hemin and vitamin K3. Iter Broth Medium (THBHM *1 ), cultured in an anaerobic environment (80vol% nitrogen, 10vol% carbon dioxide, 10vol% hydrogen) at 37°C to a steady state, and a PBS (manufactured by Wako Pure Chemical Industries, Ltd.) suspension with an absorbance of 1.0 at a wavelength of 550 nm was used for the experiment .

[0116] The strain attachment carrier uses a hydroxyapatite (HA) plate (manufactured by Asahi Optical C...

Embodiment 2

[0142] Test of the bactericidal effect on biofilm

[0143] The above method was used to evaluate the adhesion inhibitory effect of periodontal pathogenic bacteria on the composition samples with the formulations shown in Table 2 and Table 3. In addition, the biofilm model osmotic sterilization effect on these samples was also evaluated by the following method. The results are shown in Table 2 and Table 3.

[0144] (1) Preparation method of biofilm model

[0145] A carboxyapatite (HA) plate (manufactured by Asahi Optical Corporation) with a diameter of 7 mm x a thickness of 3.5 mm was soaked in non-irritating human saliva filtered through a 0.45 μm filter for 4 hours, and then used as a biofilm model Carrier; culture medium using mucin broth basal medium (BMM) *3 . The periodontal pathogenic bacterial strains used in the determination were Actinomyces viscosus ATCC43146, Veillonella parvula ATCC17745, Fusobacterium nucleatum ATCC10953, Porphyrin gingivalis purchased from th...

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Abstract

The invention discloses an inhibitor of tooth surface adhesion of periodontal pathogenic bacteria, which has a good inhibitory effect on the tooth surface adhesion of periodontal pathogenic bacteria, and discloses a biofilm formation inhibitor and a composition for oral cavity, which has a good inhibitory effect on the tooth surface adhesion of periodontal pathogenic bacteria. The tooth surface adhesion has a good inhibitory effect and has a high biofilm bactericidal effect. The tooth surface adhesion inhibitor of periodontal pathogenic bacteria is prepared from propylene glycol alginate (A). The oral biofilm formation inhibitor is prepared from propylene glycol alginate (A) and isopropylmethylphenol (B). An oral composition characterized by containing propylene glycol alginate (A) and isopropylmethylphenol (B).

Description

technical field [0001] The present invention relates to a tooth surface adhesion inhibitor of periodontal pathogenic bacteria which has an excellent inhibitory effect on the adhesion of periodontal pathogenic bacteria in the oral cavity, and relates to a tooth surface adhesion inhibitor which has a good inhibitory effect on the adhesion of periodontal pathogenic bacteria in the oral cavity and is effective in inhibiting biofilm. A biofilm formation inhibitor and a composition for oral cavity that have a high bactericidal effect and can effectively improve and prevent periodontal disease. Background technique [0002] Periodontal disease is considered to be an infectious disease caused by pathogenic bacteria attached to the oral cavity. In order to prevent and improve periodontal disease, it is very important to eliminate the pathogenic bacteria of infection. Therefore, various fungicides and antibiotics have been used. However, biofilms formed by pathogenic bacteria that c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/73A61K8/34A61K31/05A61K31/734A61K47/18A61K47/20A61P1/02A61Q11/00
CPCA61K8/347A61K8/733A61K31/05A61K31/734A61Q11/00A61Q17/005A61P1/02A61K2300/00A61K8/34A61K8/73A61K47/20
Inventor 丸山真达森岛清二
Owner LION CORP
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