Application of Uighur drug nigella glandulifera preyn seed flavone in chronic obstructive pulmonary disease drug preparation

A technology of Nigella sativa and chronic obstructive disease, which is applied in the field of NGS flavonoid medicine, can solve problems such as COPD effects that have not been reported, achieve inhibition of pulmonary bronchial smooth muscle M choline receptors, improve pulmonary bronchospasm symptoms, and stabilize anti-chronic effect of inflammation

Active Publication Date: 2013-08-21
中国人民解放军新疆军区联勤部药品仪器检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are a small number of in vitro studies reported abroad that sativa seeds can im

Method used

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  • Application of Uighur drug nigella glandulifera preyn seed flavone in chronic obstructive pulmonary disease drug preparation
  • Application of Uighur drug nigella glandulifera preyn seed flavone in chronic obstructive pulmonary disease drug preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1, the application of the Uygur medicine Nigella flavonoids in the preparation of drugs for the treatment of chronic obstructive pulmonary disease.

[0021] According to actual needs, the application of the above-mentioned Uygur medicine Nigella nigella flavonoids in the preparation of drugs for the treatment of chronic obstructive pulmonary disease can be further optimized or / and improved:

Embodiment 2

[0022] Example 2, as the above is the preferred embodiment, the NGS flavonoids are obtained by the following method: Weigh the NGS non-grease part, add the weight to the NGS non-grease weight is 6 times to 12 times the weight of NGS non-grease, the volume concentration is 30% to 60% ethanol, reflux extraction 2 to 4 times, 0.5 hours to 2 hours each time, combine the extracts, and concentrate under normal pressure at a temperature of 60°C to 80°C until there is no alcohol smell to obtain NGS flavonoids.

Embodiment 3

[0023] Embodiment 3, as above-mentioned is the preference of embodiment, the volume concentration of the ethanol used is 40%, reflux extracts 3 times, each 1.5 hours.

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Abstract

The invention relates to the technical field of NGS flavone medicine, specifically to an application of a Uighur drug nigella glandulifera preyn seed flavone in chronic obstructive pulmonary disease drug preparation. With the NGS flavones, a stable anti-chronic inflammation effect is provided for chronic bronchitis caused by chronic obstructive pulmonary diseases, lung bronchial spasm symptoms caused by chronic obstructive pulmonary diseases can be effectively improved, and generation of pulmonary bulla and emphysema can be prevented. The action mechanism relates to functions of lung bronchial smooth muscle M cholinergic receptor inhibition, and lung bronchial tissue inflammatory cell and inflammatory cytokine reduction, wherein the action mechanism is described in home and abroad researches at the first time.

Description

technical field [0001] The invention relates to the technical field of NGS flavonoids medicine, and relates to the application of flavonoids of Nigella cumulus of Uyghur medicine in the preparation of medicines for treating chronic obstructive pulmonary disease. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is a collective term for chronic airway obstructive diseases, mainly referring to chronic bronchitis and emphysema with irreversible airway obstruction. COPD patients have a poor prognosis and eventually die of respiratory failure and pulmonary diseases, which is the fourth leading cause of human death. The pathogenesis of COPD is mainly the chronic inflammation of the pulmonary bronchi, which leads to the persistence of bronchospasm, hyperactivity of cathepsin, and long-term damage to the structure of the pulmonary bronchi. There are currently no drugs that can reverse the progressive decline in lung function. Chemical drugs for the symptom...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61P11/00
Inventor 耿东升张宏涛张文斌
Owner 中国人民解放军新疆军区联勤部药品仪器检验所
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