Freezing and drying protecting agent for amyxis brucella live vaccine

A freeze-dried protective agent and skin scratch technology, which can be used in freeze-dried delivery, antibacterial drugs, bacterial antigen components, etc. Effect

Active Publication Date: 2015-01-28
NAT INST FOR FOOD & DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention provides a gelatin-free lyoprotectant for Brucella live vaccine for skin scratches, which solves the problem of vaccine allergy that may be caused by animal-derived gelatin components

Method used

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  • Freezing and drying protecting agent for amyxis brucella live vaccine
  • Freezing and drying protecting agent for amyxis brucella live vaccine
  • Freezing and drying protecting agent for amyxis brucella live vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Weigh the following substances: 20g of sucrose, 20g of sodium glutamate, and 20g of thiourea; dissolve the above substances in an appropriate amount of sterilized water for injection, dilute to 1L and adjust the pH value to 7.2 with sodium hydroxide solution; autoclave to obtain .

Embodiment 2

[0014] Weigh the following substances: 50g of sucrose, 10g of sodium glutamate, and 9g of thiourea; dissolve the above substances in an appropriate amount of sterilized water for injection, dilute to 1L and adjust the pH value to 7.4 with sodium hydroxide solution; autoclave to obtain .

Embodiment 3

[0016] Weigh the following substances: 100g of sucrose, 5g of sodium glutamate, and 5g of thiourea; dissolve the above substances in an appropriate amount of sterile water for injection, dilute to 1L and adjust the pH value to 7.3 with sodium hydroxide solution; filter and sterilize to obtain .

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Abstract

The invention discloses a freezing and drying protecting agent for an animal derived gelatin-free vaccine. The vaccine freezing and drying protecting agent takes sterile water for injection as a solvent and each litre of the freezing and drying protecting agent comprises 20-100g of saccharose, 5-20g of sodium glutamate and 5-20g of thiourea. The freezing and drying protecting agent is applied to the freezing and drying protection of a brucella live vaccine for amyxis.

Description

technical field [0001] The invention relates to a gelatin-free freeze-drying protectant for vaccines, which is used for freeze-drying protection of live Brucella vaccines for skin scratches, and belongs to the technical field of vaccine production. Background technique [0002] At present, live Brucella vaccines for skin scratches in China are all freeze-dried products. In order to ensure the live bacteria rate of Brucella in the freeze-drying process and in the process of transportation and storage of live vaccines, the existing technology is in the process of preparing live vaccines. Lyoprotectants are used in Known lyoprotectants used in the preparation of live brucella vaccines for scratches on the skin contain gelatin, sucrose, sodium glutamate and thiourea. Because the lyoprotectant contains animal-derived gelatin components, some recipients of live scratch vaccines for Brucella will show allergic reactions due to the production of IgE antibodies against gelatin in th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/26A61K47/20A61K47/18A61K47/34A61K9/19A61K39/10A61P31/04
Inventor 魏东王国治
Owner NAT INST FOR FOOD & DRUG CONTROL
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