Freezing and drying protecting agent for amyxis brucella live vaccine

A freeze-dried protective agent and skin scratch technology, which can be used in freeze-dried delivery, antibacterial drugs, bacterial antigen components, etc. Effect
CN103285399BActive Publication Date: 2015-01-28NAT INST FOR FOOD & DRUG CONTROL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NAT INST FOR FOOD & DRUG CONTROL
Publication Date
2015-01-28

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Abstract

The invention discloses a freezing and drying protecting agent for an animal derived gelatin-free vaccine. The vaccine freezing and drying protecting agent takes sterile water for injection as a solvent and each litre of the freezing and drying protecting agent comprises 20-100g of saccharose, 5-20g of sodium glutamate and 5-20g of thiourea. The freezing and drying protecting agent is applied to the freezing and drying protection of a brucella live vaccine for amyxis.
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Description

technical field

[0001] The invention relates to a gelatin-free freeze-drying protectant for vaccines, which is used for freeze-drying protection of live Brucella vaccines for skin scratches, and belongs to the technical field of vaccine production. Background technique

[0002] At present, live Brucella vaccines for skin scratches in China are all freeze-dried products. In order to ensure the live bacteria rate of Brucella in the freeze-drying process and in the process of transportation and storage of live vaccines, the existing technology is in the process of preparing live vaccines. Lyoprotectants are used in Known lyoprotectants used in the preparation of live brucella vaccines for scratches on the skin contain gelatin, sucrose, sodium glutamate and thiourea. Because the lyoprotectant contains animal-derived gelatin components, some recipients of live scratch vaccines for Brucella will show allergic reactions due to the production of IgE antibodies against gelatin in th...

Claims

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