Sophocarpidine alkaloid vaginal expansion suppository as well as preparation method and detection method thereof

A technique for vaginal expansive suppository and detection method, which is applied in the field of matrine alkaloid vaginal expansive suppository and its preparation, which can solve problems such as difficult cleaning, easy contamination of clothes, and small contact surface of active ingredients, so as to prevent outflow and avoid secondary The effect of secondary infection

Active Publication Date: 2013-09-25
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, matrine alkaloid suppositories are not easy to clean and easily contaminate clothes; the contact surface between the active ingredient and the human body is small, resulting in

Method used

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  • Sophocarpidine alkaloid vaginal expansion suppository as well as preparation method and detection method thereof
  • Sophocarpidine alkaloid vaginal expansion suppository as well as preparation method and detection method thereof
  • Sophocarpidine alkaloid vaginal expansion suppository as well as preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090]

[0091] Preparation:

[0092] 1) Preparation of drug-containing matrix:

[0093] a. The mixed fatty acid glycerides are placed in a water bath for heating and melting;

[0094] b. Pass matrine through an 80-mesh sieve, and mix it with citric acid evenly to prepare a mixture;

[0095] c. Add the mixture of step b to step a and mix well;

[0096] 2) Insert the tampon, cool and shape, and make 1000 egg-shaped suppositories, each weighing about 3.5g.

Embodiment 2

[0098]

[0099] Preparation method: make 1000 spherical suppositories according to the method in Example 1, each weighing about 5.0g.

Embodiment 3

[0101]

[0102] Preparation:

[0103] 1) Preparation of drug-containing matrix:

[0104] a. Polyethylene glycol 4000, polyethylene glycol 6000 and lanolin are placed in a water bath for heating and melting;

[0105] b. Pass the total alkaloids of Sophora flavescens through an 80-mesh sieve, and mix them evenly with ascorbic acid to prepare the mixture;

[0106] c. Add the mixture of step b to step a and mix well;

[0107] 2) Insert the tampon, cool and shape, and make 1000 duckbill-shaped suppositories, each weighing about 3.1g.

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Abstract

The invention relates to a sophocarpidine alkaloid vaginal expansion suppository as well as a preparation method and a detection method thereof. The expansion suppository comprises sophocarpidine alkaloid, a matrix and an expansion carrier; the expansion suppository further comprises an acid additive which can be used for inhibiting the sophocarpidine alkaloid from being oxidized and reducing the irritation of the sophocarpidine alkaloid to the vagina; the expansion suppository further comprises carbomer and polysorbate 80; the carbomer not only play a role of a binder, but also can form an internal salt with the sophocarpidine alkaloid, the release time of the sophocarpidine alkaloid is prolonged, the action time of the sophocarpidine alkaloid to the vagina is prolonged, and meanwhile, the irritation of the sophocarpidine alkaloid to the vagina can be reduced; the polysorbate 80 can be used for promoting the vagina to absorb the sophocarpidine alkaloid; the sophocarpidine alkaloid vaginal expansion suppository employs seven unique leading technologies and has the effective effects of preventing medicinal liquor from overflowing, being high in stability and durable in curative effect and the like.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, and in particular relates to a matrine alkaloid vaginal expansive suppository, a preparation method and a detection method thereof. Background technique [0002] Matrine alkaloids are widely found in bean plants such as Sophora flavescens, Sophora flavescens, and broad bean root. They are a group of alkaloids with similar chemical structures, including matrine, oxymatrine, sophocarpine, and sophodine. Alkali and other monomers. [0003] Matrine is an alkaloid extracted from the fruit or aerial parts of Sophora alopecuroides L. of the leguminous plant Sophora alopecuroides L. It is a white needle-like crystal or crystalline powder. Oxidation, and become light yellow; matrine is alkaline in aqueous solution, pH value is 9.5-10.5. [0004] Sophora flavescens Ait. is the total alkaloids extracted from the root of the leguminous plant Sophora flavescens Ait. The pH value is 7.5-9.5. Calculated a...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K9/02A61P15/02A61P33/02A61P31/02A61P15/00G01N33/15G01N5/04
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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