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A neural chip measurement device with high spatio-temporal resolution

A technology of nerve chip and measuring device, which is applied in the direction of electronic circuit testing, etc., can solve problems such as the absence of nerve cell stimulation methods, and achieve the effects of diversified stimulation modes, high temporal and spatial resolution, and short switching time

Inactive Publication Date: 2015-10-28
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, a high-throughput and high-spatial-resolution nerve cell stimulation method for this detection device has not yet appeared.

Method used

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  • A neural chip measurement device with high spatio-temporal resolution
  • A neural chip measurement device with high spatio-temporal resolution
  • A neural chip measurement device with high spatio-temporal resolution

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Embodiment Construction

[0035] figure 1 and figure 2 One structure of a neurochip is shown. The neurochip includes a microelectrode array and a cell growth chamber. The microelectrode array includes a substrate 1 on which microelectrodes are arranged; the cell growth chamber is fixed on the substrate 1 . The cell growth chamber includes nine microgrooves and twelve microchannels, and the nine microgrooves are arranged in an array of three rows and three columns on the substrate 1, and the top of each microgroove and microchannel is open. Two adjacent microgrooves are connected through a microchannel. For example, the first microgroove 2 and the second microgroove 3 communicate through the first microgroove 4, the second microgroove 3 communicates with the fourth microgroove 5 through the second microgroove 6, the fourth microgroove 5 and the third microgroove The microgrooves 7 communicate with each other through the third microgrooves 8 , and the third microgrooves 7 communicate with the first ...

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Abstract

The invention discloses a high-temporal-spatial-resolution nerve chip measuring device. The nerve chip measuring device comprises an optical system which carries out photostimulation on nerve cells, and a circuit system. The circuit system is used for processing electric signals collected by micro electrodes of the nerve chip. Ultraviolet faculae generated by the optical system are distributed in an arrayed mode. The arrangement manner of the ultraviolet faculae is identical with the arrangement manner of the micro electrodes on the nerve chip. The ultraviolet faculae are correspondingly lighted on the micro electrodes of the nerve chip in a one-to-one mode. A specific cell or more specific cells of a nerve cell net on the nerve chip can be stimulated with the high-temporal-spatial-resolution nerve chip measuring device, and potentials outside the cells are recorded at the same time. In addition, according to the high-temporal-spatial-resolution nerve chip measuring device, multiple-site multiple-mode photostimulation capable of being accurately controlled can be performed on the nerve cell network which grows on the measuring device in an orientated mode.

Description

technical field [0001] The present invention relates to a device for giving stimulation to nerve cells and detecting electrical signals of nerve cells. Background technique [0002] The analysis of neural electrical signals is one of the main contents of current neuroinformatics research. The more commonly used device is the micro-electrode array sensor (Micro-Electrode Array, MEA). MEA consists of microelectrodes embedded in a substrate material. Microelectrodes are mainly composed of metal materials such as platinum, gold, titanium nitride and indium tin oxide. Microelectrodes are arrayed on a substrate material. The microelectrodes are connected to wires made of gold or transparent indium tin oxide, and the wires transmit the weak electrical signals collected by the microelectrodes to an external amplifier. [0003] As an emerging research field, neural chip technology is developed on the basis of microelectrode array technology. Neurochip technology uses micro-proce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01R31/28
Inventor 叶学松田健涂春龙王飞翔
Owner ZHEJIANG UNIV
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