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Rhizoma Dryopteris Crassirhizomatis extract and its use in preparation of viral disease controlling medicines

A technology of cotton and horses, extracts, applied in the direction of antiviral agents, drug combinations, medical raw materials derived from ferns/filamentous plants, etc. and other problems, to achieve the effect of easy availability of raw materials, low cost and small side effects

Active Publication Date: 2013-10-23
承德普润生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In a word, the domestic and foreign patents of Mianma Guanzhong used alone are mainly used for reports on the efficacy of preventing and treating psoriasis, anti-tumor, anti-cancer, anti-AIDS, hepatitis virus and anti-malarial, etc., wherein the Mianma Guanzhong extract is mostly Obtained by extraction with ethanol or methanol, no ethyl acetate extraction-ethanol reflux preparation process has been seen
At the same time, there is no report on the use of extracts to prevent and treat chicken avian influenza, Newcastle disease, infectious bursa, renal infectious bronchitis, and promote or enhance the immunity of livestock and poultry.
In view of the fact that the occurrence and prevalence of viral diseases in livestock and poultry in my country has exceeded the speed of vaccine development, there is a lack of antiviral drugs for livestock and poultry in my country.

Method used

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  • Rhizoma Dryopteris Crassirhizomatis extract and its use in preparation of viral disease controlling medicines
  • Rhizoma Dryopteris Crassirhizomatis extract and its use in preparation of viral disease controlling medicines
  • Rhizoma Dryopteris Crassirhizomatis extract and its use in preparation of viral disease controlling medicines

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 Mianma Guanzhong extract

[0025] Grind 100g of Mianma Guanzhong and pass through a 60-mesh sieve, add 8 times the amount (ml / g) of ethyl acetate to the sieved material, extract for 5 hours at 25°C, and extract continuously for 3 times. Then the extracts were combined, filtered, and concentrated under reduced pressure to obtain the extract 1 of Mianmaguanzhong extract.

[0026] Add 8 times the amount (ml / g) of 70% ethanol to the remaining Mianmaguanzhong medicinal residues, reflux at 85°C for 2 hours, and extract twice continuously. Then combine the extracts, filter, recover ethanol, and concentrate under reduced pressure to obtain Mianma Guanzhong extract extract 2.

[0027] Mianmaguanzhong extract 1 and extract 2 are mixed to obtain effective active ingredients of Mianmaguanzhong.

Embodiment 2

[0028] The preparation of embodiment 2 Mianma Guanzhong extract

[0029] Grind 100g of Mianma Guanzhong and pass through a 60-mesh sieve, add 10 times the amount (ml / g) of ethyl acetate to the sieved material, extract at 25°C for 20h, and extract continuously once. Then the extracts were combined, filtered, and concentrated under reduced pressure to obtain the extract 1 of Mianmaguanzhong extract.

[0030] Add 5 times the amount (ml / g) of 75% ethanol to the remaining Mianmaguanzhong herbal residues, and extract under reflux for 3 hours, and extract continuously for 4 times. Then combine the extracts, filter, recover ethanol, and concentrate under reduced pressure to obtain Mianma Guanzhong extract extract 2.

[0031] Mianmaguanzhong extract 1 and extract 2 are mixed to obtain effective active ingredients of Mianmaguanzhong.

Embodiment 3

[0032] The preparation of embodiment 3 Mianma Guanzhong extract

[0033] Grind 100g of Mianma Guanzhong and pass through a 20-mesh sieve, add 3 times the amount (ml / g) of ethyl acetate to the sieved material, extract at 15°C for 1 hour, and extract continuously for 3 times. Then the extracts were combined, filtered, and concentrated under reduced pressure to obtain the extract 1 of Mianmaguanzhong extract.

[0034] Add 3 times the amount (ml / g) of 80% ethanol to the remaining Mianmaguanzhong medicinal residues, reflux and extract for 1 hour, and extract continuously for 3 times. Then combine the extracts, filter, recover ethanol, and concentrate under reduced pressure to obtain Mianma Guanzhong extract extract 2.

[0035] Mianmaguanzhong extract 1 and extract 2 are mixed to obtain effective active ingredients of Mianmaguanzhong.

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Abstract

The invention provides a Rhizoma Dryopteris Crassirhizomatis extract and its use in the preparation of viral disease controlling medicines. The Rhizoma Dryopteris Crassirhizomatis extract is an extract obtained through ethyl acetate extraction-ethanol refluxing extraction, can be added to drinking water or feeds to improve the humoral immunity and cellular immunity functions of animals, can control highly pathogenic avian influenza, newcastle disease virus, infectious bursal disease viruses and weaned pig diarrhea, and can also control the occurrence and epidemic of immunosuppressive diseases. The Rhizoma Dryopteris Crassirhizomatis extract has the advantages of easily available raw material, low cost, and small side effects, and is suitable for controlling the epidemic diseases of animals having impaired immunities after failed immunities.

Description

technical field [0001] The present invention relates to a kind of cotton horse with the function of improving cellular immunity and humoral immunity of livestock and poultry, and playing a role in preventing and treating viral diseases of livestock and poultry, such as diseases caused by porcine infectious diarrhea virus, avian influenza, Newcastle disease virus and infectious bursal virus. The preparation method and application of the guanzhong extract belong to the field of veterinary medicine. Background technique [0002] Since the beginning of the 21st century, the global outbreaks of livestock and poultry viral diseases such as avian influenza and Newcastle disease have not only seriously affected and hindered the healthy development of animal husbandry, but even caused their spread among humans, triggering a series of public health emergencies. The incident has caused great harm to people's health and social stability. Therefore, the research and creation of new biol...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61P31/12A61P37/04A61P31/16A61P31/14
Inventor 何诚
Owner 承德普润生物制药有限公司
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