Green method for catalytically synthesizing 2'-aminobenzothiazolyl-arylmethyl-2-naphthol

An aminobenzene and arylmethyl technology, applied in the field of organic chemical synthesis, can solve problems such as large loss, and achieve the effects of high acid density, good catalytic activity, and low environmental pollution
CN103360339BInactive Publication Date: 2015-05-13ANHUI UNIVERSITY OF TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ANHUI UNIVERSITY OF TECHNOLOGY
Publication Date
2015-05-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a green method for catalytically synthesizing 2'-aminobenzothiazolyl-arylmethyl-2-naphthol, belonging to the field of organic chemical synthesis. The method comprises the following steps: carrying out synthetic reaction, wherein the aromatic aldehyde:2-aminobenzothiazole:beta-naphthol mol ratio is 1:1:1, the bissulfonate acidic ion liquid catalyst accounts for 5-8 mol% of the aromatic aldehyde, the reaction temperature is 80-95 DEG C, the reaction time is 3-10 minutes, and the volume (ml) of the reaction solvent water is 3-5 times of the molar weight (mmol) of the aromatic aldehyde; and after the reaction is finished, cooling to room temperature, carrying out vacuum filtration, recrystallizing the filter residue with 95% ethanol, and carrying out vacuum drying to obtain the 2'-aminobenzothiazolyl-arylmethyl-2-naphthol.Compared with other synthesis methods, the invention has the characteristics of high catalytic activity, low catalyst consumption, recyclable catalyst, low environmental pollution in the whole process, simple and convenient after-treatment and the like.
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Description

technical field

[0001] The invention belongs to the field of organic chemical synthesis, and in particular relates to a green catalytic method for synthesizing 2'-aminobenzothiazole-arylmethyl-2-naphthol. Background technique

[0002] Heterocyclic compounds containing thiazole rings have broad-spectrum biological activities, can be used as local anesthetics, and have anticonvulsant, antiviral, antibacterial, insecticidal, anti-inflammatory and anti-allergic effects, and compounds containing aminothiazole rings have strong Physiologically active, it can be used to treat allergies, high blood pressure, osteoporosis, asthma, cancer, HIV virus, and also has a wide range of applications in cell biology. In addition, it is also a kind of good intermediate, and the amino functional group can undergo a series of reactions, and various compounds synthesized therefrom have a wide range of applications in medicine, pesticides, dyes, etc. Therefore, derivatives containing aminothiazole...

Claims

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