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Dentifrice composition

A technology of composition and dentifrice, which is applied in the fields of medical science, dentistry, oral care, etc., can solve the problems of reduced stability, unstable periodontal disease prevention ingredients, high gingivitis preventive effect and sense of use, etc. , to achieve the effect of reducing oral irritation, ensuring stability, and excellent stability

Active Publication Date: 2013-11-20
LION CORP
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AI Technical Summary

Problems solved by technology

[0006] However, there is such a problem that among the periodontal disease preventive ingredients, there are substances that cannot ensure stability over time under alkaline conditions (hereinafter referred to as "alkali-labile periodontal disease preventive ingredients"), such as tranexamic acid, The stability of ε-aminocaproic acid decreases over time at pH above 8.0
[0007] That is, when ascorbyl phosphate or its salt is to be mixed with the "alkali-labile periodontal disease prevention ingredient" in the dentifrice composition at the same time, if the combination is to ensure the stability of ascorbyl phosphate or its salt If the pH of the substance exceeds 8.0 at 25°C, the stability of the "alkali-labile periodontal disease prevention ingredient" will decrease over time. The stability of "preventive ingredients" cannot meet the high gingivitis prevention effect and the feeling of use at the same time.

Method used

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  • Dentifrice composition
  • Dentifrice composition
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Examples

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Embodiment

[0071] Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not limited to a following example. In addition, in the following examples, unless otherwise specified, % is all mass %.

[0072] [Example, comparative example]

[0073] The dentifrice composition of the composition shown in Table 1, 2 was prepared according to the following manufacturing method, and it evaluated by the following method. The results are shown in Tables 1 and 2.

[0074] [1] Manufacturing method of dentifrice composition:

[0075] (1) Phase A was prepared by mixing and dissolving water-soluble components (excluding the binder and propylene glycol) in pure water at room temperature.

[0076] (2) Prepare phase B in which the binder is dispersed in propylene glycol at room temperature.

[0077] (3) Phase B is added to phase A which is being stirred and mixed to prepare phase C.

[0078] (4) In phase C, use a 1.5L kneader...

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Abstract

Provided are a dentifrice composition which comprises ascorbic acid phosphate ester or a salt thereof having outstanding stability, has a good feel when used, and has decreased buccal irritation during use and after use, and a method for stabilizing ascorbic acid phosphate ester or a salt thereof in the dentifrice composition, wherein ascorbic acid phosphate ester or a salt thereof is maintained stable over time at a pH of 8.0 or less. The dentifrice composition contains (A) ascorbic acid phosphate ester or a salt thereof, and includes (B) a silica-based abrasive and (C) an alkali metal salt selected from sodium chloride, potassium chloride, sodium sulphate, and potassium sulphate, and the dentifrice composition has a pH at 25°C of 6.0-8.0. The method for stabilizing ascorbic acid phosphate ester or a salt thereof in the dentifrice composition comprises mixing constituent (B) and also constituent (C) in the dentifrice composition containing constituent (A), and making the pH at 25°C to be 6.0-8.0.

Description

technical field [0001] The present invention relates to a dentifrice composition and a method for stabilizing ascorbyl phosphate or a salt thereof in the dentifrice composition, wherein the dentifrice composition maintains ascorbyl phosphate or The stability of its salt, the stability of ascorbyl phosphate or its salt are excellent, and the irritation in the oral cavity during and after use is reduced, and the usability is good. Background technique [0002] In recent years, ascorbyl phosphate or a salt thereof has attracted attention as an antioxidant vitamin that eliminates excess active oxygen generated in a living body and protects living tissues from oxidative damage. In addition, it is well known that ascorbyl phosphate or its salt has a variety of physiological activities, and has preventive and therapeutic effects on gingivitis and periodontitis in the field of oral cavity, and it is tried to be mixed into oral compositions such as toothpaste and lozenges (refer to p...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/20A61K8/23A61K8/25A61Q11/00
CPCA61K8/676A61K8/20A61K8/23A61K8/67A61Q11/00A61K8/25
Inventor 天野步山口继乃近泽贵士宇野大介
Owner LION CORP
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