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Radix puerariae valid target and application

A technology of effective parts and active ingredients, which is applied in the field of preparation of essential hypertension drugs, can solve the problems of unreported application, and achieve the effects of less dosage, convenient carrying, and reduced hygroscopicity

Inactive Publication Date: 2013-12-04
SUZHOU FAMO BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report about the application of the effective part extract of Pueraria lobata root in the preparation of antihypertensive medicine

Method used

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  • Radix puerariae valid target and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1. Effect of Pueraria Radix Effective Parts on Blood Pressure of Spontaneously Hypertensive Rats (SHR)

[0028] (1) Experimental animals

[0029] 10-week-old spontaneously hypertensive rats (SHR), half male and half male.

[0030] (2) Experimental grouping

[0031] (1) Model control group: they were given normal saline, orally gavaged for 14 consecutive days, with a volume of 2 ml.

[0032] (2) Low-dose group of effective parts of Pueraria lobata: 60 mg / kg of effective parts of Pueraria lobata (containing 63.3% of total flavonoids of Pueraria radiata, the same below) was given by intragastric administration for 14 consecutive days, with a volume of 2 ml.

[0033] (3) Medium-dose group of the effective part of Pueraria lobata: 120 mg / kg of the effective part of Pueraria lobata was given by gavage for 14 consecutive days, and the administration volume was 2 ml.

[0034] (4) High-dose group of the effective part of Pueraria lobata: 240 mg / kg of the effective ...

Embodiment 2

[0045] Example 2. Acute Toxicity Study on Mice of Effective Parts of Pueraria lobata

[0046] (1) Purpose of the test

[0047] Investigate the toxic reaction and death situation produced by the tested animal after one-time administration (gavage) of the effective part of Pueraria lobata root.

[0048] (2) Test materials

[0049] (1) Test substance

[0050] Effective parts of kudzu root (containing 63.3% of kudzu root flavonoids)

[0051] (2) Test animals

[0052] Name: Mouse

[0053] Strain: Kunming species

[0054] Weight: 20±2g

[0055] Gender: Both male and female

[0056] Number of animals in each group: 10 (half male and half female)

[0057] Pre-treatment of the test animals: Observe the test animals in the breeding observation room 7 days in advance (room temperature: 21-23°C; relative humidity: 30-60%, 12-hour light: 8Am-8Pm), eat machine feed, drink tap water . Fasting for 16 hours before gavage administration, water supply.

[0058] (3) Test methods and re...

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Abstract

The invention belongs to the technical field of medicines, and discloses an application of a radix puerariae valid target to prepare primary hypertension medicaments. The radix puerariae valid target provided by the invention is pueraria flavonid with a content of 50% or more. The radix puerariae valid target is capable of substantially reducing blood pressure of a SHR hypertension rat. The radix puerariae valid target can be prepared into any clinically or pharmaceutically acceptable dosage form, and preferably be prepared into an oral preparation.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of effective parts of kudzu root in the preparation of essential hypertension medicine. Background technique [0002] Hypertension belongs to the category of headache, dizziness and stroke in traditional Chinese medicine, and is the most common cardiovascular disease. Traditional Chinese medicine has the characteristics of overall regulation and individualized treatment, and has unique advantages in improving the clinical symptoms of hypertension and protecting target organs. In the process of clinical and experimental research on hypertension, Chinese medical workers have summarized and studied many traditional Chinese medicine compound prescriptions and single herbs with specific curative effects, and their mechanism of action can be summarized into the following categories. [0003] 1. Inhibit the activity of the sympathetic nervous system [0004] Some hypertensive p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P9/12
Inventor 不公告发明人
Owner SUZHOU FAMO BIOLOGICAL TECH
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