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Application of serrate rabdosia herb extractive serving as STAT3 signal specificity inhibiter in preparation of anti-tumor drug

A technology of anti-tumor drugs and extracts, applied in the field of medical applications, can solve problems such as drugs that have not yet appeared, and achieve the effect of inhibiting growth

Active Publication Date: 2013-12-04
上海中科生物医学高科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the development of drugs targeting STAT3 has become recognized as an important solution for the treatment of certain tumors, but no ideal drug has yet been used in clinical practice.

Method used

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  • Application of serrate rabdosia herb extractive serving as STAT3 signal specificity inhibiter in preparation of anti-tumor drug
  • Application of serrate rabdosia herb extractive serving as STAT3 signal specificity inhibiter in preparation of anti-tumor drug
  • Application of serrate rabdosia herb extractive serving as STAT3 signal specificity inhibiter in preparation of anti-tumor drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1. Preparation of Xihuangcao extract tablets

[0041] (1) Preparation of Xihuangcao extract: 1 Kg of air-dried Xihuangcao was beaten into coarse powder (20 mesh). Add 5 L of 90% ethanol, cook in a suspension steamer for 2 h, and collect the extract; then extract the sediment with 5 L of 80% ethanol and cook in a suspension steamer for 2 h to collect the extract; mix the extract twice , Centrifuge (3000 rpm / min), take the supernatant; put the supernatant in reflux to evaporate ethanol, and concentrate to 5-100 mL of liquid to obtain the extract of Xihuangcao, set it at 4℃ for later use. See the HPLC characteristic peaks of Xihuangcao extract figure 1 .

[0042] (2) Preparation of Xihuangcao extract tablets

[0043] Formula: Xihuang grass extract (purity greater than 95%) 20.0g

[0044] Filler 180.0g

[0045] Disintegrant 10.0g

[0046] Binder 6.0g

[0047] Lubricant 3.0g

[0048] Total 200.0g

[0049] Process: Acco...

Embodiment 2

[0050] Example 2: Preparation of Xihuangcao Extract Capsules

[0051] (1) Preparation of Xihuangcao extract: same as in Example 1.

[0052] (2) Preparation of Xihuangcao extract capsules

[0053] Formula: Xihuang grass extract (purity greater than 95%) 50.0g

[0054] Filler 85.0g

[0055] Adhesive 5.0g

[0056] Lubricant 10.0g

[0057] Total 200.0g

[0058] Process: According to the conventional process of preparing capsules, 1000 capsules are made, and each capsule contains 50mg of sodium salt of the extract of Xihuangcao.

Embodiment 3

[0059] Example 3. Preparation of Xihuangcao Extract Injection

[0060] (1) Preparation of Xihuangcao extract: the same as in Example 1.

[0061] (2) Preparation of Xihuangcao Extract Injection

[0062] Formula: Xihuang grass extract (purity greater than 95%) 100.0g

[0063] Citric acid 1.0g

[0064] Sodium citrate 0.5g

[0065] Sodium chloride 18.0g

[0066] Water for injection 2000mL

[0067] Process: According to the conventional process for preparing injections, a total of 1000 2mL injections are made, and each branch of Xihuangcao extract sodium salt is 100mg.

[0068] The fillers, disintegrants, binders, lubricants and other auxiliary materials in the foregoing embodiments are the most conventional auxiliary materials in pharmacy.

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Abstract

The invention provides a new medicinal use of serrate rabdosia herb, particularly application of serrate rabdosia herb extractive serving as an STAT3 signal specificity inhibiter in preparation of an anti-tumor drug. The cell model screening experiment, Western-Blot, the semi-quantitative PCR detection and the animal experiment testify that the serrate rabdosia herb extractive has very good STAT3 inhibition activity, and can effectively inhibit the expression of related genes adjusted and controlled by STAT3, thereby effectively inhibiting the growth of tumor cells on which the STAT3 signal depends. Therefore, the serrate rabdosia herb extractive serves as the STAT3 signal specificity inhibiter, the pharmaceutically acceptable process and auxiliary materials are adopted to prepare the anti-tumor drug preparation based on STAT3 target spot, and a very good development prospect is obtained.

Description

technical field [0001] The invention belongs to the field of medical application, and relates to a new medical application of Xihuangcao extract—application as a specific inhibitor of STAT3 signal in the preparation of antitumor drugs. Background technique [0002] Xihuangcao, commonly known as bear bile grass, blood wind grass, yellow juice grass, Xigou grass, fragrant tea vegetables, natural yellow lian, etc., is mainly produced in Hunan, Sichuan, Yunnan, Jiangxi, Guangdong, Guangxi and other provinces south of the Yangtze River . In medicine, Xihuangcao has the effects of clearing heat and dampness, reducing jaundice and dampness, cooling blood and dissipating blood stasis, and is used to treat acute jaundice hepatitis, acute cholecystitis, dysentery, enteritis, traumatic injuries and other diseases. Xihuangcao is widely used clinically in various parts of Guangdong, and a variety of health care products and Chinese patent medicines with it as the main raw material have ...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P35/00
Inventor 赵晨阳唐培克张斌
Owner 上海中科生物医学高科技开发有限公司
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