Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Effective fraction of anti-osteoporosis cornus officinalis and preparation method thereof

A technology for anti-osteoporosis and effective parts, applied in medical preparations containing active ingredients, bone diseases, pharmaceutical formulas, etc., can solve the problems of large side effects and poor therapeutic effects in the human body, and achieve strong pertinence and reproducibility High sex, exact curative effect

Active Publication Date: 2013-12-25
王喜军
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problem that the existing medicines for treating osteoporosis are mainly western medicines, but the western medicines have great side effects on the human body and the treatment effect is not good, and provide anti-osteoporosis effective parts of Cornus officinalis and a preparation method thereof

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Effective fraction of anti-osteoporosis cornus officinalis and preparation method thereof
  • Effective fraction of anti-osteoporosis cornus officinalis and preparation method thereof
  • Effective fraction of anti-osteoporosis cornus officinalis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0029] Specific embodiment 1: The anti-osteoporosis effective fractions of Cornus officinalis in this embodiment are made of Cornus officinalis as a raw material, and the effective fractions of the total iridoid glycosides with a mass fraction of 85% to 95% are prepared by using macroporous adsorption resin technology group, wherein the mass fraction of morroniside in the total iridoid glycosides is 40% to 65%, and the mass fraction of loganin is 15% to 30%.

specific Embodiment approach 2

[0030] Specific embodiment two: the difference between this embodiment and specific embodiment one is that the mass fraction of morroniside in the total iridoid glycosides is 55%-65%, and the mass fraction of loganin is 16%- 30%. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0031] Specific embodiment three: the preparation method of the anti-osteoporosis effective fractions of Cornus officinalis in this embodiment is carried out according to the following steps:

[0032] 1. Weigh the medicinal material of Cornus officinalis, then add water with a mass of 5 to 7 times the mass of the medicinal material of Cornus officinalis for decoction, decoct 1 to 3 times, decoct for 1.5h to 2.5h each time, separate the decoction liquid after each decoction and medicinal dregs, collect the decoction, and then decoct the obtained medicinal dregs for the next decoction, combine each decoction and let stand for 20h to 24h, then filter with gauze under normal pressure to obtain the filtrate. Under the condition of 60-80°C, concentrate under reduced pressure to a relative density of 1.10-1.30 to obtain a concentrated medicinal solution;

[0033] 2. Add ethanol with a volume concentration of 70% to 85% to the concentrated medicinal solution obtained in step 1, so tha...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method of an effective fraction of anti-osteoporosis cornus officinalis, and relates to the preparation method of an anti-osteoporosis drug. The effective fraction of the anti-osteoporosis cornus officinalis and the preparation method thereof aim to solve the problem that most of existing drugs used for treating osteoporosis are Western medicine which have many side effects on human bodies and are not good in treatment effect. The preparation method includes the steps of (1) after weighing cornus officinalis, decocting and concentrating the cornus officinalis to obtain concentrated medical liquid, (2) carrying out water extraction by alcohol sedimentation to obtain water-extraction alcohol-sedimentation concentrated liquid, (3) preprocessing macroporous resin to obtain a resin column, (4) enabling the water-extraction alcohol-sedimentation concentrated liquid to pass through the resin column and to be eluted through ethyl alcohol so as to obtain elution liquid, and (5) carrying out vacuum distillation and recycling the step (4) so as to obtain the ethyl alcohol in the elution liquid, carrying out concentration, and finally carrying out hypobaric drying to obtain the effective fraction of the cornus officinalis.

Description

technical field [0001] The invention relates to an anti-osteoporosis medicine and a preparation method thereof. Background technique [0002] Osteoporosis is one of the most prevalent diseases in patients over middle age and represents the most prevalent public health problem, affecting more than 50% of postmenopausal women and more than 20% of men older than 50 years. Worldwide, more than 200 million people suffer from osteoporosis, including 75 million in Europe, Japan and the United States. Osteoporosis causes more than 1.5 million hip, spine and wrist fractures each year. Osteoporotic fractures can result in high mortality, high disability rates, and reduced mobility and quality of life. More than 50% of women with hip fractures require assistive devices for activities of daily living, 20% of them die within a year, and a significant number require long-term care. The aging population will inevitably increase the burden of osteoporosis and fractures for a long time to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/40A61P19/10
Inventor 王喜军张爱华孙晖
Owner 王喜军
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com