Bitterness covering agent for Chinese medicine mixture

A technology of bitter taste masking agent and mixture, applied in the field of traditional Chinese medicine mixture with good taste

Active Publication Date: 2014-01-22
HAINAN HONZ PHARMA +2
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Factors Affecting the Effect of Bitter Taste Masking Agents Are Complicated
On the one hand, the masking effect is closely related to the chemical composition, PH value, temperature, dosage form, etc. of the preparation; on the other hand, the dosage of the masking agent must be compatible with the quality requirements of the preparation, such as the efficacy of the masking agent on the drug, the relative density of the preparation, the stability In addition, the perception threshold of bitterness is very small, the duration is long, and it is not easy to eliminate; therefore, it is a challenging task for pharmaceutical workers to develop a kind of bitterness masking agent with high matching degree and good taste. high job

Method used

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  • Bitterness covering agent for Chinese medicine mixture

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Embodiment Construction

[0017] 1. Prescription

[0018] 315 grams of Scutellaria baicalensis, 180 grams of Dihuang, 160 grams of Ophiopogon japonicus, 260 grams of Scrophulariaceae, 315 grams of Forsythia.

[0019] 2. Preparation method

[0020] Take the five flavors of traditional Chinese medicine in the above prescription, crush them into coarse powder, use 57% ethanol as solvent, soak for 24 hours, slowly permeate at a speed of about 1ml per minute, collect about 6000ml of filtrate, recover ethanol under reduced pressure and concentrate to About 1400ml, add 800ml of water, boil for 30 minutes, stand still for 48 hours, filter, wash the filter residue with a small amount of water, add the lotion to the filtrate, concentrate under reduced pressure to 1000ml, add 3g of sodium benzoate, stir well, let stand for 24 hours, Filter, take the filtrate, add water to make 1000ml, stir well, that is.

[0021] 2. Preparation of liquid samples containing bitter masking agent

[0022] Get 1000ml of above-ment...

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Abstract

The invention discloses a bitterness covering agent for Chinese medicine mixture. The Chinese medicine mixture is prepared from the following raw materials in part by weight: 180 parts of rehmannia, 160 parts of radix ophiopogonis, 260 parts of radix scrophulariae, 315 parts of fructus forsythiae, 315 parts of scutellaria baicalensis, 0.2-0.8 part of neotame and 4-12 parts of extractum glycyrrhizae. Compared with the other bitterness covering agents, the bitterness covering agent has the advantages of high matching rate, few dosage, comfortable mouthfeel, high stability and the like, and the orally-taking compliance of patients is improved to a great degree, and therefore, the bitterness covering agent brings high additional value for products.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to a bitter masking agent of a traditional Chinese medicine mixture and a traditional Chinese medicine mixture with good taste. Background technique [0002] The traditional Chinese medicine mixture is prepared from 180 parts of Chinese medicinal materials, 160 parts of Radix Ophiopogon japonicus, 260 parts of Scrophulariaceae, 315 parts of Forsythia and 315 parts of Scutellaria baicalensis. It has the effects of nourishing yin, clearing the throat, and detoxifying. It is a commonly used medicine for treating localized pharyngeal diphtheria, mild toxic diphtheria, acute tonsillitis, and angina. The main active ingredients of the mixture include baicalin and forsythin, etc., and the taste is extremely bitter, which easily causes nausea and vomiting when patients take the medicine, which makes it difficult for patients to accept and affects the smooth progress of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/10A61K47/46A61P11/04A61P31/04
Inventor 洪丽萍徐吉银刘振民
Owner HAINAN HONZ PHARMA
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