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Kit for diagnosing artificial hip joint aseptic loosening

A kit and hip joint technology, applied in the direction of disease diagnosis, measuring devices, instruments, etc., to achieve the effect of early diagnosis of aseptic loosening

Inactive Publication Date: 2014-02-12
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

[0006] Aiming at the current lack of methods for diagnosing aseptic loosening of artificial hip joints, the present invention provides the application of a human sandwich ELISA kit in early diagnosis of aseptic loosening preparations of artificial hip joints

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  • Kit for diagnosing artificial hip joint aseptic loosening

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Embodiment Construction

[0012] 1. General information

[0013] From January 2011 to January 2012, peripheral venous blood samples were collected from 105 patients or healthy people, including 31 patients who planned to undergo artificial hip revision surgery (late loosening group), and 15 patients with clinical symptoms after artificial hip joint surgery. 19 patients with no loosening after artificial hip joint surgery (stable group) and 40 healthy adults. Selected cases excluded patients with metabolic bone disease, rheumatoid arthritis, autoimmune disease, immunosuppressive agents, and joint replacement due to infection or malignancy.

[0014] The surgical reasons of 34 patients with early loosening and stable prosthesis were mainly arthritis secondary to aseptic necrosis and fracture trauma (21 cases, accounting for 62%), followed by primary osteoarthritis (9 cases, accounting for 26%). %) and congenital hip dislocation (6 cases, 12%). All patients took standard X-ray films of the affected hip a...

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Abstract

The invention provides a preparation for diagnosing early-stage artificial hip joint aseptic loosening. The preparation comprises a human sandwich ELISA kit used as a preparation for diagnosing plasma interleukin 1gamma level, can also comprises a human rapid ELISA kit used as a preparation for detecting osteoprotegerin, and a Milliplex human single composite ELISA kit used as a preparation for detecting nucleus factor kappa-B acceptor activation factor ligand, or comprises any one of the three kits mentioned above. By detecting the levels of corresponding biological markers, artificial hip joint aseptic loosening can be effectively diagnosed in the early stage.

Description

technical field [0001] The invention relates to a medical diagnostic reagent, in particular to a kit for diagnosing aseptic loosening of artificial hip joints. Background technique [0002] Aseptic loosening is the most important problem in total hip arthroplasty. From the early 1960s, when Charley first used low-wear artificial hip arthroplasty to the present, people have made unremitting efforts on the pathogenesis of aseptic loosening of artificial joints. explore. In the past, this kind of non-infectious loosening was generally attributed to mechanical reasons such as poor fit between the prosthesis and bone interface, poor prosthesis installation position, and bone cement fragmentation, and it was considered to be a kind of mechanical loosening; but in recent years, people It is recognized that in addition to the above factors, the late loosening of artificial joints is mainly related to the biological response induced by the particles produced by the long-term wear or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543
CPCG01N33/6869G01N33/6803G01N33/6872G01N2333/54G01N2800/10
Inventor 何涛武文黄研张晓玲汤亭亭戴尅戎
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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