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Application of a Serrata Serrata Extract in the Preparation of Medicines for Treating Leukemia

A technology of S. serrata and its extract is applied to the application field of S. serrata extract in the preparation of medicines for treating leukemia, and can solve problems such as no reports on S. serrata or S. serrata extract yet.

Inactive Publication Date: 2015-08-19
ZHONGSHAN TIANTIAN ANIMAL HEALTH CARE TECHNOLOGICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned documents and patents, etc., have not yet seen the report of Serenia serrata or Serenia serrata extract being used to prepare drugs for the treatment of leukemia

Method used

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  • Application of a Serrata Serrata Extract in the Preparation of Medicines for Treating Leukemia
  • Application of a Serrata Serrata Extract in the Preparation of Medicines for Treating Leukemia
  • Application of a Serrata Serrata Extract in the Preparation of Medicines for Treating Leukemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: the preparation of Sara serrata extract

[0036] (1) Serpentine 20kg, add water to soak for 6 hours, extract volatile oil by steam distillation, extraction time 2 hours, extraction times 2 times, add water 14 times of the weight of Serpentine, collect volatile oil, and obtain Serpentine extract A; filtering the Serrata serrata water extract to obtain extract A and dregs A respectively;

[0037](2) Use 70% ethanol as a solvent to extract the dregs A obtained in step (1), heat and reflux extraction, the number of extractions is 2 times, each extraction time is 2 hours, and the amount of solvent used each time is 12 times the weight of Serrata serrata , filtered, the extract recovered ethanol, concentrated and dried to obtain Serrata serrata extract B;

[0038] (3) Concentrate the medicinal solution A obtained in step (1) to a relative density of d=1.12, filter, and pass the medicinal solution through LSA-21 macroporous adsorption resin, first elute with wat...

Embodiment 2

[0040] Embodiment 2: the preparation of Sara serrata extract

[0041] (1) Serpentine 25kg, add water to soak for 4 hours, extract volatile oil by steam distillation, extraction time 1 hour, extraction times 3 times, add water 8 times the weight of Serenia, collect volatile oil, and obtain Serpentine extract A; filtering the Serrata serrata water extract to obtain extract A and dregs A respectively;

[0042] (2) Use 50% ethanol as a solvent to extract the dregs A obtained in step (1), heat and reflux for extraction, the number of extractions is 1 time, each extraction time is 3 hours, and the amount of solvent used each time is 15 times the weight of Serrata serrata , filtered, the extract recovered ethanol, concentrated and dried to obtain Serrata serrata extract B;

[0043] (3) Concentrate the drug solution A obtained in step (1) to a relative density of d=1.10, filter it, pass the drug solution through a macroporous adsorption resin, elute with water first, then elute with ...

Embodiment 3

[0045] Embodiment 3: the preparation of Sara serrata extract

[0046] (1) Serpentine 19kg, add water and soak for 12 hours, extract volatile oil by steam distillation, extraction time is 4 hours, extraction times 1 time, add water 15 times of the weight of Serpentine, collect volatile oil, and obtain Serpentine extract A; filtering the Serrata serrata water extract to obtain extract A and dregs A respectively;

[0047] (2) Use the dregs A obtained in step (1) with ethanol at a concentration of 95% as a solvent, heat and reflux for extraction, the number of extractions is 3 times, each extraction time is 1 hour, and the amount of solvent used each time is 8 times the weight of Serrata serrata , filtered, the extract recovered ethanol, concentrated and dried to obtain Serrata serrata extract B;

[0048] (3) Concentrate the drug solution A obtained in step (1) to a relative density of d=1.20, filter it, and pass the drug solution through a macroporous adsorption resin, elute wit...

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Abstract

The invention relates to an application of a Boraginaceae extract to the preparation of a medicine for treating leukemia and belongs to the field of medicines. The preparation method of the Boraginaceae extract is as follows: Boraginaceae which is used as a raw material is extracted by the use of ethanol at different concentrations after volatile oil is extracted, and the extracted Heteropappus altaicus is purified by macroporous adsorption resin so as to obtain the Boraginaceae extract, including a Boraginaceae extract A, a Boraginaceae extract B and a Boraginaceae extract C. The Boraginaceae extract can be combined with a pharmaceutically acceptable carrier or other appropriate excipient so as to prepare an oral dosage form by a conventional method. The Boraginaceae extract provided by the invention can be used in the preparation of a medicine for treating leukemia.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of a Chinese herbal medicine extract in the preparation of a medicine for treating leukemia, in particular to the application of a Serrata serrata extract in the preparation of a medicine for treating leukemia. Background technique [0002] Leukemia is a malignant disease that originates from the hematopoietic system and is characterized by the production and accumulation of a large number of immature and abnormal white blood cells in the bone marrow or other hematopoietic tissues. From the perspective of form, most leukemia cells are immature and abnormally morphological white blood cells; in terms of function, leukemia cells have the same characteristics as tumor cells: leukemia cells are tumorous proliferation, which cannot be controlled, and often leads to the inhibition and failure of bone marrow hematopoietic function. It can cause anemia, neutropenia and thrombocytope...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/30A61P35/02
Inventor 骆焕丽尚曙玉沈永杰王琰王世广张景亮
Owner ZHONGSHAN TIANTIAN ANIMAL HEALTH CARE TECHNOLOGICAL
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