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Use of neuregulin 1

A kind of neuregulin, the technology of use, applied in the field of biomedicine

Inactive Publication Date: 2014-03-05
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether it can play a role in lead poisoning encephalopathy has not been reported

Method used

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  • Use of neuregulin 1
  • Use of neuregulin 1
  • Use of neuregulin 1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Application of neuregulin 1 in preparation of medicine for treating lead poisoning encephalopathy.

[0017] 1. Materials and methods

[0018] 1. Animal grouping

[0019] C57BL / 6 was purchased from the Experimental Animal Center of Zhengzhou University, male, 6 months old. Lead acetate animal model modeling: the classic lead poisoning encephalopathy modeling method was adopted: intraperitoneal injection of lead acetate solution 30 mg / kg body weight, once every other day, a total of 7 injections. After 7 injections of lead acetate, the animals were randomly divided into two groups: NRG1β1-treated group and control group. Animals in each group were free to forage for food and drink water.

[0020] 2. Reagent preparation

[0021] Human NRG1β1 (R&D Corporation). NRG1β1 or saline were treated by intraperitoneal injection for 14 days (50 ng / kg / day dissolved in 0.9% NaCl, referred to as vehicle-treated group).

[0022] 3. Tissue preparation, immunohistochemistry

[0023]...

Embodiment 2

[0066] The use of neuregulin 1 in this example includes the following steps: taking an effective amount of neuregulin 1 and dissolving it in physiological saline to prepare an injection, and intramuscularly injecting it for the treatment of toxic encephalopathy caused by heavy metals.

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Abstract

The invention discloses use of neuregulin 1, belongs to the technical field of a biomedicine, and particularly relates to application of the neuregulin 1 inpreparation of a drug for treating lead encephalopathy. The characteristics of the lead encephalopathy are high expression of inflammatory cells and inflammatory factors and wide neuronal cell death. Neuron loss and nerve inflammatory reaction play a crucial role in the lead encephalopathy process. The neuregulin 1 has a significant nerve inflammatory reaction and a role of protecting cell apoptosis in the lead encephalopathy, can inhibit inflammatory activation, reduces the quantities of microglial cells and astrocytes, reduces the expression level of inflammatory cytokines COX-2, and improves the learning and memory defects caused by lead poisoning. In addition, the quantity of ErbB4 positive cells can be increased by the neuregulin 1; the inhibition apoptosis activity of anti-apoptosis protein Bc1-2 is improved; expression of pro-apoptotic protein Bax is reduced, so that apoptosis is inhibited, and neuregulin 1 has significant neuroprotective effects on the lead encephalopathy.

Description

technical field [0001] The invention relates to the use of neuregulin 1, in particular to the application of neuregulin 1 in the preparation of medicines for treating lead poisoning encephalopathy, and belongs to the technical field of biomedicine. Background technique [0002] Lead (Pb) is one of the common heavy metal environmental pollutants, which has become a major problem endangering human health. Long-term exposure to lead in small doses can cause damage to multiple systems, especially the nervous system. Lead exposure activates inflammatory cells such as astrocytes and microglia in the mouse brain, and the activated inflammatory cells secrete inflammatory factors such as COX-2, iNOS, IL-6, etc. These inflammatory factors Can induce apoptosis, resulting in reduced learning and memory ability. Intraventricular injection of lead can reduce the ability of learning and memory in mice. [0003] Apoptosis is closely related to lead poisoning encephalopathy. Jiang Junjun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61P39/02A61P25/00A61P25/28
Inventor 杨彩玲邓晓慧毕凌云宋海岩孙春莉
Owner XINXIANG MEDICAL UNIV
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