Compound cantharides traditional Chinese medicine composition and use of preparation thereof in preparation of medicine for treating radiation-induced pulmonary injury

A radiation-induced lung injury and composition technology, applied in the field of preparation of drugs for the treatment of radiation-induced pulmonary fibrosis, can solve problems such as no radiation-induced lung injury treatment effect

Inactive Publication Date: 2014-03-26
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although previous studies have shown that the compound mylabris preparation can be used to prepare drugs for treating tumors, regulating immunity and other diseases, there are no patent documents and research reports on the therapeutic effect of the compound mylabris preparation on radiation-induced lung injury

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] (1) Weigh the raw materials according to the following ratio:

[0070] Mylabris 3.97g, Ginseng 9.92g, Astragalus 49.58g, Acanthopanax 49.58g, Sanleng 15.83g, Scutellaria barbata 59.5g, Curcuma 15.83g, Cornus officinalis 19.83g, Ligustrum lucidum 19.83g, bear bile powder 0.4g, licorice 9.92g

[0071] (2) Preparation method:

[0072] The above eleven flavors, except bear bile powder, ginseng, dogwood, Ligustrum lucidum, and Scutellaria barbata are crushed into fine powder, sieved, and set aside; Mylabris is extracted by soaking in chloroform three times, 95.2ml each time, soaked for 72 hours, combined The extract was recovered with chloroform and concentrated to a thick paste; the other five flavors such as Astragalus were decocted three times with water, the first time was 3 hours, the second time was 1.5 hours, and the third time was 1 hour, the decoction was combined, filtered, and the filtrate was concentrated to a relatively high temperature. The density is about 1...

Embodiment 2

[0074] (1) Weigh the raw materials according to the following ratio:

[0075] Mylabris 0.6g, Ginseng 1.5g, Astragalus 7.5g, Acanthopanax 7.5g, Trigonum 2.4g, Banzhilian 9.0g, Curcuma 2.4g, Cornus officinalis 3g, Ligustrum lucidum 3g, Bear bile powder 0.05g, Licorice 1.5g

[0076] (2) Preparation method:

[0077] Eleven flavors in the recipe, except for bear bile powder, crushed mylabris into 60-mesh fine powder, extracted 4 times with water, added 22 times the amount of water for the first time, soaked for 30 minutes, extracted for 2 hours, and added 15 times the amount for the second time water, extract for 1 hour, add 12 times the amount of water for the third time, extract for 1 hour, add 10 times the amount of water for the fourth time, extract for 1 hour, filter, and combine the filtrate; the remaining 9 flavors of ginseng and other ginseng are extracted with water for 3 times , add 15 times the amount of water for the first time, soak for 1 hour, extract for 4 hours, ad...

Embodiment 3

[0079] (1) Weigh the raw materials according to the following ratio:

[0080] Mylabris 6.0g, Ginseng 15g, Astragalus 100g, Acanthopanax 100g, Trigonum 24g, Banzhilian 100g, Curcuma 24g, Cornus officinalis 30g, Ligustrum lucidum 30g, Bear bile powder 1.0g, Licorice 15g

[0081] (2) Preparation method:

[0082]The preparation method is as follows: the eleven flavors in the recipe, except for the bear bile powder, the mylabris is crushed into a 60-mesh coarse powder, and the water is extracted 3 times, the first time is added with 20 times the amount of water, soaked for 40 minutes, extracted for 1.5 hours, the second, Add 15 times the amount of water each time for three times, extract for 1.0 hour, filter, combine the filtrate, add ethanol until the alcohol content reaches 80%, let it stand, filter, and concentrate the filtrate under reduced pressure to form a thick paste, add 8 times the amount of water, Stir, stand still, filter, the filtrate is centrifuged at a speed of 1000...

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PUM

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Abstract

The invention relates to a compound cantharides traditional Chinese medicine composition and use of preparation thereof in preparation of medicine for treating radiation-induced pulmonary injury, especially use in preparation of medicine for treating radiation pulmonary fibrosis. The compound cantharides traditional Chinese medicine composition is composed of eleven components such as cantharides, ginseng, radix astragali, acanthopanax root, trigone, Sculellaria barbata, is prepared by adding corresponding auxiliary materials on the basis of a traditional Chinese medicine composition and using a common method, so that a new treatment medicine is provided for radiation-induced pulmonary injury disease and clinic application of the compound cantharides preparation is expanded.

Description

technical field [0001] The invention relates to the new application of compound mylabris traditional Chinese medicine composition and its preparation in preparing medicine for treating radiation-induced lung injury, especially the application in preparing medicine for treating radiation-induced pulmonary fibrosis. technical background [0002] In recent years, due to the high incidence of lung cancer and esophageal cancer, radiation therapy, as one of the effective methods for treating malignant tumors, has a history of more than 100 years and has become an important means of treatment for these tumors. [0003] Radiation therapy for thoracic malignant tumors began in the 1920s. With clinical practice, it was found that the sensitivity of lung tissue to radiation was the main factor limiting radiation therapy for thoracic tumors. Inappropriate radiation doses or long-term use of radiation therapy were extremely harmful. May cause lung damage. In 1922, Hines reported two cas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P11/00A61K35/413A61K35/64
Inventor 窦啟玲
Owner GUIZHOU YIBAI PHARMA CO LTD
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