Application of kinesin and its homologues in the preparation of drugs for the treatment of diabetic complications

A technology of kelkinin and diabetes, applied in the field of medicine, to achieve the effects of less addiction, no tolerance and addiction, and less side effects

Active Publication Date: 2016-01-20
FUJIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no literature report on the effect of kinesin on the treatment of diabetic complications and its possible use

Method used

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  • Application of kinesin and its homologues in the preparation of drugs for the treatment of diabetic complications
  • Application of kinesin and its homologues in the preparation of drugs for the treatment of diabetic complications
  • Application of kinesin and its homologues in the preparation of drugs for the treatment of diabetic complications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Improvement of hyperalgesia in diabetic rats by subcutaneous injection of kelkinin in the back of the neck.

[0027] 1.1 Drugs and reagents:

[0028] Gelkinin is extracted, separated and purified from the natural plant Gelkins by the applicant of the present invention, see Patent No.: 200810071469.9, the title of the invention is "Method for Separating and Preparing Gelkins Alkaloid Monomers from Gelkins by High-speed Countercurrent Chromatography" and Patent No. 2011101746576 The disclosed technology is the prior art with a purity of >98.5% (accurately weigh keloids, dissolve with 1mol / l HCl, dilute with normal saline, adjust pH with 1mol / l NaOH (4

[0029] 1.2 Animals:

[0030] SD rats, m...

Embodiment 2

[0042] Improvement of nerve conduction impairment in diabetic rats by subcutaneous injection of kelezin in the back of the neck.

[0043] 2.1 Drugs and reagents:

[0044] Kiskinin is obtained by the applicant of the present invention by extracting, separating and purifying the natural plant Gelkins, with a purity of >98.5% (accurately weigh kelkinin, dissolve it with 1mol / l HCl, dilute with normal saline, adjust the pH with 1mol / lNaOH (4

[0045] 2.2 Animals:

[0046] SD rats, male, 180-220g, provided by Shanghai Slack Animal Center. They were raised at room temperature at 25°C under a light-dark cycle of 12 / 12h, free to eat and drink, and used for formal experiments after 3 days of adaptation to th...

Embodiment 3

[0057] Improvement of neurofiber pathology in diabetic rats by subcutaneous injection of kelkinin in the back of the neck.

[0058] 3.1 Drugs and reagents:

[0059] Kiskinin is obtained by the applicant of the present invention by extracting, separating and purifying the natural plant Gelkins, with a purity of >98.5% (accurately weigh kelkinin, dissolve it with 1mol / l HCl, dilute with normal saline, adjust the pH with 1mol / lNaOH (4

[0060] 3.2 Animals:

[0061] SD rats, male, 180-220g, provided by Shanghai Slack Animal Center. They were raised at room temperature at 25°C under a light-dark cycle of 12 / 12h, free to eat and drink, and used for formal experiments after 3 days of adaptation to the labo...

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PUM

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Abstract

The invention discloses the application of kelsin and its homologues in the preparation of drugs for treating diabetic complications. Mouse neuropathy, see Example 1 for details, has a large safe treatment window, may not be tolerated, addictive and has few side effects, and is suitable for the preparation of drugs for treating diabetic complications. Potentially significant economic effects. Kiskinin and its homologues or pharmaceutically acceptable salts thereof have applications in the preparation and treatment of diabetic complications. They do not have the disadvantages of the above two types of commonly used clinical drugs for treating diabetic complications. They are developed in accordance with the national innovative drug approval method and are expected to become an effective treatment for diabetic complications. Diabetic complications (diabetic hypersensitivity and nerve fiber degeneration), intolerance and addiction, and small side effects, a national Class 1 new drug for the treatment of diabetic complications with independent intellectual property rights in my country, has a clear industrialization prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of koumine alkaloid monomers, in particular to the application of koumine and its homologues in the preparation of medicines for treating diabetic complications. Background technique [0002] Complications of diabetes include diabetic neuropathy and pain, among others. Among them, diabetic neuropathy is the most common, which can affect the central and peripheral nerves, especially distal sensory neuropathy, which accounts for more than 50% of all diabetic neuropathies. The specific symptoms are hyperalgesia, decreased peripheral nerve conduction velocity, and nerve fiber degeneration. etc. seriously affect the quality of life. Drug therapy is currently one of the main means of clinically treating patients with diabetic complications, and gabapentin is currently the first-line drug for treating diabetic peripheral neuropathy. As of 2011, there were 366 million diabetic pat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/475A61P3/10A61P25/00A61P29/00
Inventor 俞昌喜刘铭凌倩许盈黄慧慧杨渐苏燕评
Owner FUJIAN MEDICAL UNIV
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