A fluorescence molecular tomography device and method based on a single slip ring and wirelessly controlled excitation light scanning

Abstract

The invention discloses a fluorescent molecular tomography device and method based on a single slip ring and wireless control exciting light scanning and belongs to the field of fluorescent molecular tomography technologies. The device comprises a slip ring power supply module, a wireless control exciting light scanning module, a rotation mirror module, an optical acquisition module and a push-pull type objective table module. Laser beams emitted from a laser tube in the exciting light scanning module enters a two-dimensional scanning galvanometer, and the two-dimensional scanning galvanometer deflects and reflects the laser beams under the control of a wireless data transmission module and enables the laser beams to be directly projected to an imaged object on an objective table. Fluorescent light excited by the imaged object passes through a reflective light path of the rotation mirror module, enters the optical acquisition module and is collected by the optical acquisition module. Through the wireless control exciting light scanning mode, control signal lines are omitted, so the problem that the signal lines are twined due to rotation does not exist, the usage frequency of the slip ring is reduced, the design complexity of the system is reduced, and the size of the system is decreased.

Description

technical field [0001] The invention belongs to the technical field of fluorescent molecular tomography, and in particular relates to a fluorescent molecular tomographic imaging device and method based on a single slip ring and wirelessly controlled luminescence scanning. Background technique [0002] Fluorescence in vivo imaging can observe molecular and cellular biological activities at the living level, so it has received extensive attention and development. The goal of Fluorescence molecular tomography (FMT) is to detect fluorescent photons from the surface to accurately locate and quantify the distribution of fluorescent probes inside the imaging object, which has become a research hotspot in recent years. In this method, on one side, an excitation spot (laser light of a certain wavelength) is scanned at different positions on the surface of the imaged object. Excitation light entering the imaged object excites fluorophores within it to fluoresce. On the other side, t...

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Problems solved by technology

Although a large flat mirror is used to deflect the light path, the space occupied by the device is still relatively large; secondly, the device cannot realize the push-pull imaging object placement method, and the operator is easy to touch the optical components such as the mirror when the imaging object is placed , affecting operational safety

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