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Compound nasal gel for treating allergic rhinitis and preparing method thereof

A kind of allergic rhinitis, compound technology, applied in the field of gel preparation, can solve the problems of difficult mucosal absorption, obvious adverse reactions, nasal mucosal atrophy, etc., achieve long retention time, good therapeutic effect, and reduce discomfort

Inactive Publication Date: 2014-04-23
孙迎东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its adverse reactions are obvious, and long-term application can easily cause nasal mucosal atrophy
[0003] At present, most of the nasal drops commonly used in clinical practice are liquid preparations, which are easy to flow into the mouth from the nasal cavity, resulting in bitterness in the mouth and difficulty in being absorbed by the mucous membranes.

Method used

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  • Compound nasal gel for treating allergic rhinitis and preparing method thereof
  • Compound nasal gel for treating allergic rhinitis and preparing method thereof
  • Compound nasal gel for treating allergic rhinitis and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059]

[0060]

[0061] (1) Take carbomer and disperse it in distilled water, let it stand overnight, and stir well to obtain solution A;

[0062] (2) Suspend baicalin in distilled water and add it to solution A to obtain solution B;

[0063] (3) Add borax to distilled water and heat to dissolve, let it cool down and add it to solution B, and stir until transparent yellow colloidal liquid C;

[0064] (4) Add ethyl paraben to distilled water, heat to dissolve and let cool to obtain solution D;

[0065] (5) Dissolve ephedrine hydrochloride in distilled water to obtain solution E;

[0066] (6) Menthol is dissolved in ethanol to obtain solution F;

[0067] (7) Add solution D, solution E, solution F and glycerin to yellow colloidal liquid C in sequence, then add the remaining distilled water, stir well, and you get it.

Embodiment 2

[0069]

[0070] (1) Take carbomer and disperse it in distilled water, let it stand overnight, and stir well to obtain solution A;

[0071] (2) Suspend baicalin in distilled water and add it to solution A to obtain solution B;

[0072] (3) Add borax to distilled water and heat to dissolve, let it cool down and add it to solution B, and stir until transparent yellow colloidal liquid C;

[0073] (4) Add ethyl paraben to distilled water, heat to dissolve and let cool to obtain solution D;

[0074] (5) Dissolve ephedrine hydrochloride in distilled water to obtain solution E;

[0075] (6) Menthol is dissolved in ethanol to obtain solution F;

[0076] (7) Add solution D, solution E, solution F and glycerin to yellow colloidal liquid C in sequence, then add the remaining distilled water, stir well, and you get it.

Embodiment 3

[0078]

[0079] (1) Take carbomer and disperse it in distilled water, let it stand overnight, and stir well to obtain solution A;

[0080] (2) Suspend baicalin in distilled water and add it to solution A to obtain solution B;

[0081] (3) Add borax to distilled water and heat to dissolve, let it cool down and add it to solution B, and stir until transparent yellow colloidal liquid C;

[0082] (4) Add ethyl paraben to distilled water, heat to dissolve and let cool to obtain solution D;

[0083] (5) Dissolve ephedrine hydrochloride in distilled water to obtain solution E;

[0084] (6) Menthol is dissolved in ethanol to obtain solution F;

[0085] (7) Add solution D, solution E, solution F and glycerin to yellow colloidal liquid C in sequence, then add the remaining distilled water, stir well, and you get it.

[0086] The clinical curative effect of compound recipe baicalin nasal drop gel of the present invention:

[0087] 1. Diagnostic criteria and case selection

[0088...

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PUM

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Abstract

The invention belongs to the field of gel preparation and particularly relates to compound nasal gel for treating allergic rhinitis and a preparing method thereof. The compound nasal gel is prepared from baicalin, carbomer, ephedrine hydroehloride, borax, glycerin, ethylparaben, menthol, ethanol and distilled water. The nasal gel spray has the advantages of accurate therapeutic effect, stable properties and small adverse reaction is prepared through the selection of the baicalin which has remarkable antimicrobial, anti-inflammatory and anti-allergic effects, the cold-irritating menthol and a low dosage of ephedrine hydroehloride and the use of the high-molecular carbomer as a carrier. The compound nasal gel is used for treating allergic rhinitis.

Description

technical field [0001] The invention belongs to the field of gel preparation, in particular to a compound nasal drop gel for treating allergic rhinitis and a preparation method thereof. Background technique [0002] Allergic rhinitis (allergic rhintis, AR), also known as allergic rhinitis, is an IgE-mediated IgE-mediated release after an atopic individual touches an allergen, and a variety of immune active cells and cytokines are involved. Chronic inflammatory response disease of the nasal mucosa, the clinical manifestations are sneezing, runny nose, nasal congestion and nasal itching. According to literature reports, AR is a common disease in the world at present. Epidemiological research reports that its prevalence rate is 10%-25% worldwide. In my country, about 10 million people suffer from the disease every year, and the incidence rate is about 37.74%. See ( Brozek JL, Bousguet J, Baena-Cagnani CE, et al. Allergicrhinitis and its impact on asthma (ARIA) guidelines: 2010r...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/7048A61K47/32A61P11/02A61P37/08
Inventor 汪风芹孙迎东胡丽敏成文娜
Owner 孙迎东
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