Compound red sage root orally-disintegrating tablet and preparation method thereof

Abstract

The invention provides a compound red sage root orally-disintegrating tablet, which is composed of the following components by weight: 50 mg of red sage root extract, 10 mg of safflower extract, 8 mg of pseudo-ginseng extract, 8 mg of gynostemma pentaphylla extract, and the balance being auxiliary materials which are acceptable in the orally disintegrating tablet manufacturing technology. The invention also provides a preparation method of the compound red sage root orally disintegrating tablet. The preparation method takes red sage root and safflower as the main materials, then adopts pseudo-ginseng and gynostemma pentaphylla as the assisting components so as to solidify the curative effect to achieve the expected treatment result; furthermore, and also adopts a combined disintegrating agent composed of microcrystalline cellulose and cross-linked sodium carboxymethyl cellulose, wherein the mass ratio of the microcrystalline cellulose to the cross-linked sodium carboxymethyl cellulose is 30:15, and the combined disintegrating agent can promote the tablet to completely disintegrate within a minute; the tablet can avoid the liver first-pass effect, has the advantages of good taste, no grittiness, and user-friendliness, is especially suitable for patients who have difficulty in swallowing or for the waterless condition, can improve the obedience of patients, and improves the curative effect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a compound salvia miltiorrhiza orally disintegrating tablet and a preparation method thereof. Background technique [0002] In real life, cardiovascular and cerebrovascular diseases such as coronary heart disease and angina pectoris are common and frequently-occurring diseases that endanger the health of most middle-aged and elderly people. At present, there is no good cure. In recent years, with the improvement of people's living standards and the increase of life pressure, such diseases are on the rise. Most of the existing traditional Chinese medicine oral preparations for the prevention and treatment of such diseases need to be taken with water, which is extremely inconvenient for some special groups of people, such as the elderly, bedridden elderly with long-term stroke, and patients with dysphagia. The active ingredient has low purity and low bioava...

AI Technical Summary

Problems solved by technology

Most of the existing traditional Chinese medicine oral preparations for the prevention and treatment of such diseases need to be taken with water, which is extremely inconvenient for some special groups of people, such as the elderly, bedridden elderly with long-term stroke, and patients with dysphagia. Active ingredients have low purity and low bioavailability

However, the ingredients of traditional Chinese medicine injections currently on the market are relatively complex, and their safety and compliance are low. For example, Danhong injection has gradually exposed some problems during clinical use for many years, such as: unstable curative effect, prone to allergic reactions, and prone to severe Diarrhea, static guanitis, liver damage, etc.

[0003] Therefore, in the prior art, there has not been found a kind of active ingredient with high purity, high bioavailability, and easy to take, which is conducive to the popularization of medicines for the treatment and prevention of cardiovascular and cerebrovascular diseases such as coronary heart disease and angina pectoris.