Xiangsha (Chinese character) oral emulsion for nourishing stomach and preparation method thereof

A technology for stomach-oral emulsion and fragrant sand to nourish the stomach, which is applied in the directions of pharmaceutical formula, emulsion delivery, and medical preparations containing active ingredients, etc., to achieve the effects of improving acceptance, good taste and sufficient release.

Active Publication Date: 2014-04-23
江西广恩和药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no disclosure of Xiangsha Yangwei Oral Emulsion in the prior art.

Method used

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  • Xiangsha (Chinese character) oral emulsion for nourishing stomach and preparation method thereof
  • Xiangsha (Chinese character) oral emulsion for nourishing stomach and preparation method thereof
  • Xiangsha (Chinese character) oral emulsion for nourishing stomach and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1: Preparation of fragrant sand nourishing stomach medicinal liquid and volatile oil

[0047] Take 70g Muxiang, 70g Amomum, 100g Atractylodes Atractylodes, 100g Chenpi, 100g Poria, 100g Pinellia (made from vinegar), 70g Cyperus cyperi (made from vinegar), 70g Zhishi (stir-fried), cardamom (removed) Shell) 70 g, magnolia officinalis (made from ginger) 70 g, patchouli 70 g, licorice 30 g, ginger 30 g and jujube 50 g to extract the volatile oil together, collect the volatile oil for later use, and decoct the remaining medicinal residue with water twice, 50 minutes each time, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.16 at 75°C, add ethanol to make the alcohol content 80%, let it stand for 45 hours, take the supernatant to recover the ethanol, and the remaining liquid Add appropriate amount of water, adjust the pH value to 4.0, let it stand for 45 hours, and filter to obtain the fragrant sand nourishing st...

Embodiment 2

[0049] Example 2: Preparation of fragrant sand nourishing stomach medicinal liquid and volatile oil

[0050] Take 70g Muxiang, 70g Amomum, 100g Atractylodes Atractylodes, 100g Chenpi, 100g Poria, 100g Pinellia (made from vinegar), 70g Cyperus cyperi (made from vinegar), 70g Zhishi (stir-fried), cardamom (removed) Shell) 70 g, magnolia officinalis (made from ginger) 70 g, patchouli 70 g, licorice 30 g, ginger 30 g and jujube 50 g to extract volatile oil together, collect the volatile oil for later use, and decoct the remaining medicinal residues with water for 3 times, 60 minutes each time, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.18 at 75°C, add ethanol to make the alcohol content 80%, let it stand for 48 hours, take the supernatant to recover the ethanol, and the remaining liquid medicine Add an appropriate amount of water to adjust the pH to 4.2, let it stand for 48 hours, and filter to obtain the fragrant sand n...

Embodiment 3

[0052] Example 3: Preparation of Xiangsha Nourishing Stomach Oral Emulsion

[0053] prescription:

[0054] The fragrant sand stomach nourishing medicinal liquid of embodiment 1 80% (g / 100ml) The volatile oil of embodiment 1 0.9% (g / 100ml) long chain triglycerides 3% (g / 100ml) Soy lecithin 9% (g / 100ml) tert-butyl p-hydroxyanisole 0.5% (g / 100ml) Ethylparaben 0.05% (g / 100ml) Propylparaben 0.05% (g / 100ml) Water for Injection margin

[0055] Preparation method: Mix volatile oil, long-chain triglycerides, tert-butyl-p-hydroxyanisole, ethylparaben and propylparaben evenly to obtain an oil phase, keep warm at 60°C for later use; Liquid, soybean lecithin and water for injection are mixed and dissolved, then added to the oil phase, magnetically stirred at 60°C for 30 minutes, cut with a high-speed shearer at a speed of 6000 rpm for 15 minutes, potted and sterilized to obtain an oral emulsion .

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Abstract

The invention discloses a xiangsha (Chinese character) oral emulsion for nourishing the stomach, comprising the following components: (i) 60-85% of xiangsha stomach-nourishing soup and 0.5-1.2% of volatile oil, (ii) 1.0-15% of medicinal oil, (iii) 3.0-25% of emulsifier, (iv) 0-10% of auxiliary emulsifying agent, (v) 0.005-1.0% of antioxidant, (vi) 0-1.5% of preservative and the balance of water. The xiangsha oral emulsion for nourishing the stomach is simple in preparation technology, low in production cost, good in stability and high in bioavailability.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to an oral emulsion for nourishing the stomach with fragrant sand and a preparation method thereof. Background technique [0002] Xiangsha Yangwei Pill is a variety recorded in the first part of the Chinese Pharmacopoeia in 2000. It is widely used in clinical practice. Its main function is to warm the middle and stomach. The prescription is composed of 14 traditional Chinese medicines: woody, Amomum, Atractylodes macrocephala, tangerine peel, poria, pinellia, Cyperus cyperi, Citrus aurantium, cardamom, Magnolia officinalis, patchouli, licorice, ginger, and jujube. Among them, woody, Amomum, Atractylodes macrocephala, tangerine peel, Cyperus cyperi, Citrus aurantium, cardamom, Magnolia officinalis, Patchouli, and ginger have high volatile oil content, which can relieve gastrointestinal smooth muscle spasm, regulate qi, and warm Stomach digestion, promote th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/107A61P1/14
Inventor 毛欣李翔黄燕刘薇叶楚清罗晓健傅宝庚陈平
Owner 江西广恩和药业股份有限公司
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