Fish skin gelatin hollow capsules and preparation method thereof

A technology of fish skin gelatin and hollow capsules, which is applied in the direction of capsule delivery, can solve the problems of high toxicity and side effects, and achieve the effects of complete sterilization, simple biodegradability, and enhanced memory

Inactive Publication Date: 2014-05-14
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the ethylene glycol esters, ethylene glycol ethers, and chloroethanols produced by the action of ethylene oxide and amino acids in gelatin have greater toxic and side effects on the human body.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh 23 kg of gelatin obtained from dried tilapia skin, add 77 kg of distilled water, let it swell for 10 minutes, heat and dissolve at a constant temperature of 65oC, then add 1.15 kg of glycerin, 100 g of sodium dodecylsulfonate and stir evenly to obtain a flowing Glue solution, the glue solution is ultrasonically degassed at a frequency of 100kHz. After the above-mentioned degassed glue solution is omitted from the upper air bubble layer, the capsule abrasive mold rod is immersed in the glue solution, and the mold rod is immersed for about 15 seconds. The rod is lifted, and the cold water freezes quickly after turning it over 4 times. Dry at a constant temperature of 60°C for 60 minutes, remove the shell, and obtain tilapia skin gelatin hollow capsules.

[0028] The hollow capsules prepared above are sterilized by ozone, the time for ozone sterilization is 0.5 minutes to 10 minutes, and the ozone pressure for ozone sterilization is 0.1MPa to 0.3MPa.

Embodiment 2

[0030] Weigh 25 kg of gelatin obtained from dried cod skin, add 75 kg of distilled water, let it swell for 10 min, heat and dissolve at a constant temperature of 65°C, then add 2 kg of glycerin, 100 g of sodium dodecylsulfonate and stir evenly to obtain a flowing Glue solution, the glue solution is ultrasonically degassed at a frequency of 120kHz. After the above-mentioned degassed glue solution is omitted from the upper air bubble layer, the capsule abrasive mold rod is immersed in the glue solution, and the mold rod is immersed for about 15 seconds. The rod is lifted, and the cold water freezes quickly after turning it over 4 times. Dry at a constant temperature of 50°C for 90 minutes, and remove the shell to obtain cod skin gelatin hollow capsules.

Embodiment 3

[0032] Weigh 20 kg of gelatin obtained from dried tilapia skin, add 80 kg of distilled water, let it swell for 10 minutes, heat and dissolve at a constant temperature of 60°C, then add 1.3 kg of glycerin and 100 g of sodium dodecylsulfonate and stir evenly to obtain Flowing glue, the glue is ultrasonically degassed at a frequency of 100kHz. After the above-mentioned degassed glue is omitted from the upper air bubble layer, the capsule abrasive mold rod is immersed in the glue liquid, and the mold rod is immersed for about 15 seconds. The mold rod is lifted, and the cold water solidifies quickly after turning over 4 times. Dry at a constant temperature of 40°C for 120 minutes, and remove the shell to obtain tilapia skin gelatin hollow capsules.

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PUM

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Abstract

The invention relates to preparation of hollow capsules, specifically to marine animal fish skin gelatin hollow capsules and a preparation method thereof. The fish skin gelatin hollow capsules comprise the following four components by weight, 15-50% of fish skin gelatin, 0.1-30% of a plasticizer, 0.001-10% of a surfactant and 40-80% of water. According to the present invention, the adopted fish skin gelatin has characteristics of good film formation, good safety, good biocompatibility and good biodegradability, is a high quality protein resource, and has effects of human immunity increase and memory enhancement; the preparation method has characteristics of simple operation, easily available raw materials and significantly reduced hollow capsule production cost; and the obtained hollow capsules do not have the excessive heavy metal problem, do not contain hydroxybenzoate esters and other harmful preservatives, and do not adopt ethylene oxide and other sterilization processes.

Description

Technical field: [0001] The invention relates to the preparation of a hollow capsule, in particular to a marine animal fish skin gelatin hollow capsule and a preparation method thereof. Background technique: [0002] Capsules are often used to fill medicines and health foods. They have a bright appearance, can mask the odor of medicines, are easy to swallow, and are easy for consumers to accept. The bioavailability of functional factors is high, the amount of excipients is small, and they disintegrate quickly in the intestinal tract. Generally, it can disintegrate and release functional substances in 3-10 minutes after taking it; compared with pills and tablets, capsules have the advantages of quick effect, good absorption, good stability, and long shelf life, and are very popular among consumers. [0003] There are three major drawbacks in existing gelatin hollow hard capsules: [0004] A. In recent years, the outbreak and prevalence of animal infectious diseases such as "...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48
Inventor 闫鸣艳李莉莉秦松邹文婷
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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