Application of wedelolide in the preparation of anti-pulmonary fibrosis drugs

Abstract

The invention relates to a drug application of a chemical substance wedelolactone for treatment of pulmonary fibrosis. The chemical substance wedelolactone is derived from a traditional Chinese medicine eclipta, and the structure is determined through spectral data; the wedelolactone can significantly improve the degree of model mouse lung tissue pulmonary fibrosis after intragastric administration, reduce NO (Nitrogen Oxide) and MDA (Methylene dioxyamphetamine) contents reflecting degree of lung injury, HYP (Hydroxyproline) content reflecting collagen deposition in the lung tissues, and cell factor TGF-beta 1 (Transforming Growth Factor) content causing pulmonary fibrosis, and inhibit human embryo lung fibroblast proliferation in vitro and HYP content of the human embryo lung fibroblast. In-vivo and in-vitro experiments show that wedelolactone can obviously improve bleomycin induced mouse pulmonary fibrosis, so that the wedelolactone can be taken as a novel drug for treating pulmonary fibrosis.

Description

technical field [0001] The invention relates to a new application of chemical substance wedelolide as a drug for treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis is a progressive disease characterized by fibrosis and lung parenchymal remodeling. Pulmonary fibroblasts hyperproliferate, transdifferentiate into myofibroblasts, secrete a large amount of collagen and deposit matrix. There is no effective treatment. Bleomycin-induced pulmonary fibrosis animal model is the most commonly used. Pulmonary fibrosis induced by tracheal administration of bleomycin is a classic animal model for studying pulmonary fibrosis drugs at home and abroad. Bleomycin can cause inflammation and fibrosis of lung tissue in a short period of time, and increase pro-fibrotic markers such as TGF -Expression of β1, α-SMA, etc. Generally speaking, the bleomycin animal model begins to show fibrosis symptoms 9 days after modeling, and typical fibrosis symptoms appear on 21 days ...

AI Technical Summary

Problems solved by technology

The general treatment of emphysema drugs is ineffective or poor in the treatment of pulmonary fibrosis, because the drugs that relax the bronchi cannot finally slow down or stop the excessive deposition of collagen in the lung tissue, and collagen deposition is the main feature of pulmonary fibrosis and etiology

[0005] At present, there is no literature report that wedelolide has the effect of treating pulmonary fibrosis and its application in the treatment of pulmonary fibrosis

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