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Anhydrous sodium sulfate powder and preparation method thereof

An anhydrous sodium sulfate and sodium citrate technology, applied in the direction of sulfur/selenium/tellurium active ingredients, digestive system, powder delivery, etc., can solve the problems of reduced patient compliance, disturbance of electrolyte balance, difficulty in swallowing, etc. Clinical use, clinical application safety, and the effect of solving the salty taste

Inactive Publication Date: 2014-07-16
KECHUANG HLDG GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Glauber's salt solution has a strong salty and astringent taste. After oral administration, the patient feels a strong salty and astringent taste, which makes it difficult to swallow, which greatly reduces the patient's compliance.
In addition, oral administration of Glauber's salt solution can partially lose ions in the body, causing electrolyte balance disorder

Method used

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  • Anhydrous sodium sulfate powder and preparation method thereof
  • Anhydrous sodium sulfate powder and preparation method thereof

Examples

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Effect test

Embodiment 1

[0047] The preparation of embodiment 1 powder of the present invention

[0048] An anhydrous sodium sulfate powder used for cleaning the intestinal tract before clinical operations or colonoscopy examinations. It is prepared according to the ratio of the following drugs: anhydrous sodium sulfate 100.0g, sodium saccharin 0.2g (0.2%), sorbitol 5g (5 %), potassium chloride 0.5g (0.5%), sodium chloride 2.5g (2.5%), sodium citrate 0.8g (0.8%). Put the above-mentioned 6 kinds of medicines into a blender and stir them fully for 0.5 hours, then pulverize them with a pulverizer for 0.5 hours, pass through a 100-mesh sieve, and pack the obtained medicinal powder into 5g / bag, which is anhydrous sodium sulfate powder. Each bag of powder contains 4.6g of anhydrous sodium sulfate.

Embodiment 2

[0049] Embodiment 2: the preparation of powder of the present invention

[0050] An anhydrous sodium sulfate powder used for cleaning the intestinal tract before clinical operations or colonoscopy examinations. It is made of the following drugs according to the ratio: anhydrous sodium sulfate 1500.0g, aspartame 7.5g (0.5%), potassium chloride 13.5g (0.9%), sodium chloride 30.0g (2%), sodium citrate 10.5g (0.7%). Above-mentioned 5 kinds of medicines are packed into blender and fully stirred for 40 minutes, then pulverized by pulverizer for 40 minutes, crossed 100 mesh sieve, and the obtained medicated powder is sealed and packed into 10g / bag, which is anhydrous sodium sulfate powder. Each bag of powder contains 9.6g of anhydrous sodium sulfate.

Embodiment 3

[0051] Embodiment 3: the preparation of powder of the present invention

[0052] An anhydrous sodium sulfate powder used to clean the intestinal tract before clinical operations or colonoscopy examinations. It is made of the following drugs according to the ratio: anhydrous sodium sulfate 5000.0g, sodium saccharin 4.0g (0.08%), xylitol 500.0g (10%), potassium chloride 50.0g (1.0%), sodium chloride 110.0g (2.2%), sodium citrate 50.0g (1.0%). Put above-mentioned 6 kinds of medicines into blender and fully stir for 45 minutes, then pulverize through pulverizer for 1 hour, pass through 100 mesh sieves, the obtained medicine powder is sealed and packed into 20g / bag, and becomes anhydrous sodium sulfate powder. Each bag of powder contains 17.5g of anhydrous sodium sulfate.

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Abstract

The invention provides anhydrous sodium sulfate powder, which comprises the following raw materials by weight ratio: 100 parts of a main drug of anhydrous sodium sulfate, a flavouring which is composed of one or several raw materials of 0.02-0.5 parts of sodium saccharin, 0.1-0.6 parts of aspartame, 1.5-15 parts of sorbitol, 1.5-15 parts of xylitol, and 0.02-0.5 parts of asccharin; and an electrolyte of 0.5-1 part of potassium chloride and 2-3 part of sodium chloride; and a pH conditioning agent of 0.5-1 part of sodium citrate. The invention also provides a preparation method of the powder. The powder is suitable for cleaning intestinal tract before clinic operation or enteroscopy inspection, the cleaning effect of intestinal tract is good, incidence rate of adverse reaction is low, and the problems that mouthfeel of an anhydrous sodium sulfate solution is salty and bitter, the electrolyte in a process for cleaning intestinal tract is lost, so that balance of the electrolyte is disordered. The powder is suitable for people of all ages.

Description

technical field [0001] The invention relates to an anhydrous sodium sulfate powder and a preparation method thereof. Background technique [0002] Bowel cleansing is an important preparation for gastrointestinal surgery, colonoscopy, and imaging examinations (urinary tract, colonography, CT, etc.). Commonly used clinical intestinal cleansing methods include cleansing enema and oral drug catharsis. Cleansing enema is a traditional intestinal cleansing method. It is still suitable for those who need colon examination or surgery for suspected intestinal obstruction because they do not need to drink liquid. Cleansing enema is divided into three types: soapy water enema, glycerin enema, and colon perfusion machine method. Due to the cumbersome operation, the amount of clinical use is gradually decreasing. Oral drug catharsis is to take osmotic, irritating, and volumetric laxatives to clean the intestinal tract, and is currently the most commonly used method. [0003] At presen...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K33/04A61P1/10
Inventor 祝传宝陈长雄何俊明赵志伟孙承铭姜沁邑
Owner KECHUANG HLDG GRP
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