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Medicine for treating Wegener's granulomatosis with pulmonary symptoms as the first manifestation and preparation method thereof

A technology of Wegener's granulomatosis and drugs, which is applied in the field of medicine and can solve problems such as unreported Wegener's granulomatosis

Inactive Publication Date: 2016-03-23
滨州医学院附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are no reports of specific drugs for Wegener's granulomatosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Angelica 1000g, Licorice 500g, Shuanghua 1500g, Yuanshen 1500g, Gypsum 200g, Bellflower 500g.

[0023] Preparation:

[0024] a. Add water to decoct angelica, licorice, root ginseng, gypsum, platycodon grandiflorum for two times, add 5 times the volume of medicine for the first time and decoct for 2 hours, add water for 3 times the volume of medicine for the second time and decoct for 1.5 hours , combined decoction, and filtered; the filtrate was concentrated at 60°C to a concentrated solution with a relative density of 1.22 to 1.26, let it cool, added ethanol until the alcohol content reached 80%, stirred well, stood at room temperature for 12 hours, and filtered; the filtrate was 60 Recover ethanol at ℃ and concentrate to a thick paste with a relative density of 1.35-1.38;

[0025] b. add honey and water to the thick paste prepared in step a to make ointment, and prepare 1000g altogether.

[0026] Usage and dosage: 50g each time, 2-3 times a day, 10 days as a course ...

Embodiment 2

[0028] Angelica 900g, Licorice 550g, Shuanghua 1400g, Yuanshen 1600g, Gypsum 180g, Campanulaceae 550g.

[0029] Preparation:

[0030] a. Add water to decoct angelica, licorice, root ginseng, gypsum, platycodon grandiflorum for two times, add 4 times the volume of the drug for the first time and decoct for 1.5 hours, add 2 times the volume of the drug for 1 hour and decoct for the second time , combined decoction, and filtered; the filtrate was concentrated at 60°C to a concentrated solution with a relative density of 1.22 to 1.26, let it cool, added ethanol until the alcohol content reached 80%, stirred well, stood at room temperature for 12 hours, and filtered; the filtrate was 60 Recover ethanol at ℃ and concentrate to a thick paste with a relative density of 1.35-1.38;

[0031] b. Add honey and water to the thick paste prepared in step a to make granules, and prepare 1000g altogether.

[0032] Usage and dosage: 50g each time, 2-3 times a day, 10 days as a course of treatm...

Embodiment 3

[0034] Angelica 1000g, Licorice 450g, Shuanghua 1600g, Yuanshen 1400g, Gypsum 220g, Bellflower 450g.

[0035] Preparation:

[0036] a. Add water to decoct angelica, licorice, root ginseng, gypsum, platycodon grandiflorum for two times, add 6 times the volume of medicine for the first time and decoct for 2.5 hours, add water for 5 times the volume of medicine for the second time and decoct for 2 hours , combined decoction, and filtered; the filtrate was concentrated at 60°C to a concentrated solution with a relative density of 1.22 to 1.26, let it cool, added ethanol until the alcohol content reached 80%, stirred well, stood at room temperature for 12 hours, and filtered; the filtrate was 60 Recover ethanol at ℃ and concentrate to a thick paste with a relative density of 1.35-1.38;

[0037] b. add honey and water to the thick paste prepared in step a to make ointment, and prepare 1000g altogether.

[0038] Usage and dosage: 50g each time, 2-3 times a day, 10 days as a course ...

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PUM

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Abstract

The invention belongs to the technical field of medicines and particularly relates to a medicine for treating Wegner granulomatosis with pulmonary symptoms as first clinical manifestation and a preparation method of the medicine. The medicine for treating Wegner granulomatosis with pulmonary symptoms as first clinical manifestation is prepared from the following traditional Chinese medicine raw materials in parts by weight: 80-120 parts of angelica sinensis, 40-60 parts of liquorice, 130-170 parts of double blossoms, 130-170 parts of radix scrophulariae, 16-24 parts of gypsum and 40-60 parts of platycodon grandiflorum. The total effective rate of the medicine for treating Wegner granulomatosis with pulmonary symptoms as first clinical manifestation reaches up to 85.71%.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a medicine for treating Wegener's granulomatosis with pulmonary symptoms as the first manifestation and a preparation method thereof. Background technique [0002] Wegener's granulomatosis (WG) is a necrotizing granulomatous inflammatory disease of medium and small blood vessels of unknown etiology, mainly involving the upper and lower respiratory tract and kidneys, with clinical manifestations of multiple tissues and organs throughout the body In damaged syndrome, about 80% of the lungs are involved, and its clinical symptoms are not specifically different from other lung diseases. Especially cases with pulmonary symptoms as the first manifestation are easily misdiagnosed, thereby delaying its diagnosis and treatment. [0003] There are no reports of specific drugs for Wegener's granulomatosis. Contents of the invention [0004] In order to solve the above techn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/808A61P29/00A61P11/00A61K33/06
Inventor 宋德海边瑞民王滨满玉清高新富石效荣
Owner 滨州医学院附属医院
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