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Liver protecting drug

A drug, hepatitis B technology, applied in the field of Chinese patent medicines for liver protection drugs, can solve the problem of poor treatment effect of hepatitis B

Inactive Publication Date: 2014-08-06
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a new composition of Chinese herbal medicine with hepatoprotective effect, so as to solve the problem of poor therapeutic effect of hepatitis B

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0006] 1. Preparation of hepatitis B granules:

[0007] 1. A liver-protecting drug formulation of hepatitis B granules: 8g (grams) each of Ligustrum lucidum, Eclipta chinensis, Scutellaria officinalis, Bupleurum chinensis, Salvia miltiorrhiza, Helicobacter sp. A total of 80g.

[0008] 2. The hepatitis B granules (YGKL) according to claim 1, wherein the preparation method of the granules is as follows: the optimum water extraction process of the hepatitis B granules is 10 times the amount of water, decocted 3 times, 1.5 hours each time. The best granulation method is dry paste powder: starch: dextrin: sucrose=5:6:4:2.

[0009] 2. Contents of pharmacodynamics research:

[0010] 1. Study on the protective effect of Yigan Granules on chemical liver injury and immune liver injury in mice.

[0011] 2. Study on the anti-liver fibrosis effect and mechanism of Yigan Granules in rats.

[0012] 3. The effect of B-gan granule and its drug-containing serum on hepatic stellate cells.

...

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Abstract

The invention develops an anti-HBV drug, i.e., a hepatitis B granule, according to folk experience about treatment of hepatitis and the theory of traditional Chinese medicine. The hepatitis B granule is formed by combination of a plurality of Chinese herbal medicines consisting of glossy privet fruit, eclipta herba, spatholobus stem, Chinese thorowax root, red sage root, canton love-pea vine, Japanese climbing fern spore, common selfheal fruit-spike, virgate wormwood herb, European verbena herb and the like. The objective of the invention is to develop a novel natural medicinal preparation for treatment of hepatitis B. According to long-term considerable research of the inventor, the hepatitis B granule and drug serum thereof can inhibit propagation of hepatic HSC-T6 and collagen synthesis and exert obvious protection effects on acute chemical liver injury of mice caused by carbon tetrachloride, paracetamol, D-galactosamine and the like, immunological liver injury caused by concanavalin A and chronic hepatic fibrosis of rats. The hepatitis B granule provided by the invention may possibly become a novel liver protecting drug for patients with acute liver injury and chronic hepatic fibrosis. According to the invention, Guangxi characteristic crude drug resources are dug and systemized, and the novel natural medicinal preparation is provided for treatment of acute liver injury and chronic hepatic fibrosis.

Description

technical field [0001] The invention relates to a liver-protecting medicine, in particular to a Chinese patent medicine for liver-protecting medicine prepared by using Chinese herbal medicines as raw materials. Background technique [0002] Liver disease refers to acute and chronic liver diseases including viral hepatitis, fatty liver, alcoholic liver and other causes. In addition to viral infection, liver damage caused by various liver-damaging factors may have pathological features of hepatocyte necrosis, inflammation and secondary fibrosis. Liver injury is not an independent disease name, but a pathological change, which is the common pathological basis of all types of liver diseases. Chemical and drug damage is acute and chronic liver damage caused by chemical toxic substances such as carbon tetrachloride, D-galactosamine and other factors. Liver fibrosis refers to the pathological process in which the proliferation and degradation of extracellular matrix such as colla...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K9/16A61P1/16A61P31/20
Inventor 黄仁彬杨欣王丽惠葛文漪何开嫩林兴方芳郭雪峰陈庆全
Owner GUANGXI MEDICAL UNIVERSITY
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