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Preparation method of Yiqing granules

A technology of granules and Coptis chinensis, applied in the field of preparation of Yiqing granules, can solve the problems that ordinary people dare not use Yiqing granules with confidence, the solubility of Yiqing granules is unqualified, and affects the solubility of granules, etc., and achieves qualified solubility and is easy to promote , easy-to-grasp effect

Active Publication Date: 2015-10-21
SICHUAN FENGCHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, Yiqing Granules is a national essential drug. According to the principle of full coverage of essential drug sampling inspections, in recent years, the State Drug Administration has stepped up random inspections of Yiqing Granules, which also exposed the problems of Yiqing Granules: multiple spot checks The solubility of Yiqing Granules is not up to standard, which makes the common people afraid to use Yiqing Granules with confidence, and also confuses the pharmaceutical manufacturers.
"Although this preparation method has considered in the extraction stage that the mixed extraction of several medicinal materials will generate precipitation and cause the loss of active ingredients, it has ignored the reaction that will occur after mixing to form macromolecules that are insoluble in water when preparing granules. Salts, which in turn affect particle solubility

Method used

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  • Preparation method of Yiqing granules
  • Preparation method of Yiqing granules
  • Preparation method of Yiqing granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032](1) Take 264g of Coptidis rhizome, 800g of rhubarb, and 400g of Scutellaria baicalensis, add water to decoct 3 times respectively, the first time is 1.5h, the second and third times are 1h each, the decoctions are combined, filtered, and the filtrate is concentrated under reduced pressure to 70°C to measure the relative time The clear paste with a density of 1.15 was spray-dried to obtain Coptidis rhizome dry extract powder, Rhubarb dry extract powder and Scutellaria baicalensis dry extract powder;

[0033] (2) Take the Coptidis Rhizoma dry extract powder prepared in step (1), add 100 g of dextrin and 3 g of sodium cyclamate, mix well, add 20 ml of 40% ethanol aqueous solution, make granules, and dry to obtain Coptidis Rhizoma Granules;

[0034] (3) Take the rhubarb dry extract powder obtained in step (1), add 300 g of dextrin and 6 g of sodium cyclamate, mix well, add 50 ml of ethanol aqueous solution containing sodium hydroxide (hydrogen in ethanol aqueous solution cont...

Embodiment 2

[0038] (1) Take 320g of Coptidis rhizome, 700g of rhubarb and 450g of Scutellaria baicalensis, decoct with water for 3 times respectively, 1.5h for the first time, 1h for the second and 3 times respectively, combine the decoctions, filter, and concentrate the filtrate under reduced pressure to 70°C to measure the relative time The clear paste with a density of 1.10 was spray-dried to obtain Coptidis rhizome dry extract powder, Rhubarb dry extract powder and Scutellaria baicalensis dry extract powder;

[0039] (2) Take the Coptidis Rhizoma dry extract powder prepared in step (1), add 100 g of lactose and 5 g of sodium cyclamate, mix well, add 15 ml of 20% ethanol aqueous solution, make granules, and dry to obtain Coptidis Rhizoma Granules;

[0040] (3) Take the rhubarb dry extract powder obtained in step (1), add lactose 300g, sodium cyclamate 5g, mix well, add 45ml of ethanol aqueous solution containing sodium hydroxide (hydroxide in ethanol aqueous solution containing sodium h...

Embodiment 3

[0044] (1) Take 150g of Coptidis rhizome, 600g of rhubarb, and 200g of Scutellaria baicalensis, decoct with water for 3 times, 1.5 hours for the first time, 1 hour for the second and third times, combine the decoctions, filter, and concentrate the filtrate to 70°C under reduced pressure to measure the relative time The clear paste with a density of 1.08 was spray-dried to obtain Coptidis rhizome dry extract powder, Rhubarb dry extract powder and Scutellaria baicalensis dry extract powder;

[0045] (2) Take the Coptidis rhizome dry extract powder obtained in step (1), add 47 g of soluble starch and 3 g of sodium cyclamate, mix well, add 10 ml of 50% ethanol aqueous solution, make granules, and dry to obtain Coptidis rhizome granules;

[0046] (3) Get the rhubarb dry extract powder obtained in step (1), add 196g of soluble starch, 4g of sodium cyclamate, mix well, add 40ml of ethanol aqueous solution containing sodium hydroxide (hydrogen in ethanol aqueous solution containing sod...

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Abstract

The invention discloses a Yiqing granule preparing method. The method comprises the following steps: respectively extracting dry extract powder from rhizoma coptidis, rheum officinale and radix scutellaria; adding a pharmaceutically-acceptable auxiliary material in the dry extract powder of rhizoma coptidis, evenly mixing, and adding an ethanol-water solution or water so as to prepare rhizoma coptidis granules; adding a pharmaceutically-acceptable auxiliary material in the dry extract powder of rheum officinale, evenly mixing, and adding a sodium hydroxide water solution or an ethanol-water solution containing sodium hydroxide so as to prepare rheum officinale granules; adding a pharmaceutically-acceptable auxiliary material in the dry extract powder of radix scutellariae, evenly mixing, and adding a sodium hydroxide water solution or an ethanol-water solution containing sodium hydroxide so as to prepare radix scutellaria granules; finally mixing rhizoma coptidis granules, rheum officinale granules and radix scutellaria granules to obtain mixed granules, and sub-packaging the mixed granules in bags, thereby obtaining Yiqing granules. The Yiqing granules prepared by virtue of the method have qualified dissolubility and a strong curative effect and are safe and effective to take; besides, the technology is simple; the application prospect is broad.

Description

technical field [0001] The invention relates to a preparation method of medicine, in particular to a preparation method of Yiqing granule. Background technique [0002] Yiqing granule is a traditional Chinese medicine granule drug recorded in the 2010 edition of "Chinese Pharmacopoeia". Clinically, it is widely used for fever, irritability, red eyes and mouth sores, sore throat and gums, constipation, hematemesis, hemoptysis, hemorrhoids, pharyngitis, tonsillitis, and gingivitis caused by fire, poison and blood heat. With the improvement of people's living standards, fear of getting angry and wanting to get angry are problems that many people often encounter, so the daily use of Yiqing Granules is very large. [0003] However, Yiqing Granules is a national essential drug. According to the principle of full coverage of essential drug sampling inspections, in recent years, the State Drug Administration has stepped up random inspections of Yiqing Granules, which also exposed t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61K9/16A61K47/04A61P1/02A61P1/10A61P9/14A61P11/04
Inventor 钟茂团黎勇吴诗惠何德中古莉
Owner SICHUAN FENGCHUN PHARMA
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