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Device, system and methods for the oral delivery of therapeutic compounds

A technology for delivering devices and reactants, which can be used in the field of delivery of other medicines, various components of the device, and can solve problems such as needle stick pain and infection risk.

Active Publication Date: 2014-08-13
RANI THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional alternative drug delivery methods such as intravenous and intramuscular delivery have a number of disadvantages including: pain and risk of infection from needle sticks; need to use sterile technique; needs and associated risks
While other drug delivery methods such as implantable drug delivery pumps have been employed, these require the device to be implanted semi-permanently and may still have many of the limitations of intravenous delivery

Method used

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  • Device, system and methods for the oral delivery of therapeutic compounds
  • Device, system and methods for the oral delivery of therapeutic compounds
  • Device, system and methods for the oral delivery of therapeutic compounds

Examples

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Embodiment Construction

[0051] Embodiments of the invention provide devices, systems and methods for delivering drugs to various locations in the body. As used herein, the term "drug" refers to any form of pharmaceutical preparation, which may include a drug or other therapeutic agent and one or more pharmaceutical excipients. Many embodiments provide swallowable devices for drug delivery within the gastrointestinal tract. Certain embodiments provide swallowable devices, such as capsules, for drug delivery to the wall of the small intestine or other gastrointestinal organ.

[0052] Referring now to Figure 1- Figure 9 , an embodiment of a device 10 for delivering a drug 100 to a delivery site DS in the gastrointestinal (GI) tract comprises a capsule 20 sized to be swallowed and passed through the intestinal tract, a deployment member 30, a capsule containing the drug 100 or a plurality of tissue penetrating members 40 , deployable aligners 60 and delivery mechanisms 70 . The deployable aligner 60 ...

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Abstract

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and / or degraded within the GI tract.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 61 / 571,641, filed June 29, 2011, entitled "Device, System and Methods for the Oral Delivery of Therapeutic Compounds"; It is hereby incorporated by reference in its entirety for this purpose. [0003] This application is also a continuation-in-part of U.S. Patent Application No. 12 / 978,233 and No. 12 / 978,301, both filed on December 23, 2010, and both titled "Swallowable Drug Delivery Device and Methods of Drug Delivery"; The content of this application is hereby incorporated herein for all purposes. Background technique [0004] Embodiments of the present invention relate to swallowable drug delivery devices. More specifically, embodiments of the present invention relate to swallowable delivery devices for delivering therapeutic agents to the small intestine. [0005] Although new drugs for treating various diseases have been increasingly dev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M31/00
CPCA61B5/073A61B5/4839A61B5/14539A61M31/002
Inventor 米尔·伊姆兰
Owner RANI THERAPEUTICS