Lozenge capable of improving anoxia endurance, and preparation method and application thereof

A technology of tolerance and preparation steps, which is applied in the field of buccal tablets for improving hypoxia tolerance and its preparation, can solve the problems of high toxicity and side effects, inconvenient taking, etc., and achieve strict compatibility, reasonable prescription design, and low price Effect

Inactive Publication Date: 2014-08-20
徐艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many drugs and supplements that are clinically used to improve hypoxia tolerance, but these varieties have relatively large toxic and side effects...

Method used

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  • Lozenge capable of improving anoxia endurance, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 20g of Fushengcao, 30g of morel ginseng, 20g of copper hammer jade belt grass, 20g of tribulus terrestris, 20g of calamus and 20g of noon vanilla, add water and decoct twice, each time adding water is 10 times the weight of the medicinal materials, decoct for 2 hours, Combine the decoctions, concentrate to 65°C when the relative density is 1.10, add ethanol, stir, so that the alcohol content reaches 65% by volume percentage, let stand, filter, the filtrate is concentrated under reduced pressure to 65°C when the relative density is 1.20 and recovered Ethanol to obtain concentrated solution, spray drying, spray drying conditions are: air inlet temperature is 100 ℃, air outlet temperature is 70 ℃, material temperature is 80 ℃, atomization pressure is 0.4 MPa, spray speed is 5ml / s, add sucrose , Granulated, compressed, made into buccal tablets.

Embodiment 2

[0015] Example 2: Pharmacodynamic research on improving hypoxia tolerance

[0016] Experimental animals: Kunming mice, male, weighing 18-22 g, provided by Shanghai Slack Experimental Animal Co., Ltd., production license: SCXK (Shanghai) 2007-0005.

[0017] Experimental drug: prepared according to the preparation method of the above-mentioned Example 1 to obtain 100 tablets, each 1 g, containing 1.3 g of crude drug.

[0018] Dosage: According to the "Equivalent Dose Ratio Table Between Humans and Animals Converted by Body Surface", the dosage for a 70-kg person per day is 130g, and the dosage for each 20g mouse per day is 130*0.0026=0.338g, because Each lozenge contains 1.3g of crude drug in 1g, that is, the consumption of each mouse is 0.26g, so it is determined that the small dose is administrated with 0.26g tablet, and the middle dose and high dose are administrated with 0.52g and 1.04g respectively.

[0019] Positive drug Jinri brand Xinyuansu Capsules, Xiamen Jinri Scienc...

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PUM

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Abstract

The invention discloses a lozenge capable of improving anoxia endurance. The lozenge comprises 10 to 30 parts of iris confuse, 20 to 40 parts of lousewort root, 15 to 25 parts of pratia nummularia, 10 to 30 parts of caltrop, 10 to 30 parts of tofieldia thibetica, and 10 to 30 parts of stickyhair pearleverlasting herb. The invention also discloses a preparation method of the lozenge. The preparation method comprises the following steps: decocting with water; concentrating; precipitating with alcohol; spray-drying; crushing the obtained particles into dry extract powder; adding auxiliary materials; then preparing into the lozenge. The invention also discloses application of the lozenge in preparation of a medicine for improving anoxia endurance.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a buccal tablet for improving hypoxia tolerance and a preparation method and application thereof. Background technique [0002] Every organ in the human body needs oxygen, and each organ has a different demand for oxygen. For example, the oxygen consumption of the brain is 25% of the total oxygen consumption of the human body, and the heart is 18%. These two organs consume the most oxygen. When the oxygen supply or utilization rate is reduced, the organs will be hypoxic, which will cause various chronic diseases (hypoxia is the source of all diseases), and of course acute hypoxia will cause suffocation and death. The improvement of hypoxia tolerance refers to the reduction of the organ's demand for oxygen, but at the same time, the organs can work normally. There are many drugs and supplements that are clinically used to improve hypoxia toleranc...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/20A61P39/00
Inventor 徐艳
Owner 徐艳
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