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External use drug capable of improving microcirculation, clearing and activating channels and collaterals, promoting blood circulation removing stasis and treating rheumatism bone diseases and preparation method thereof

A technology for promoting blood circulation and removing blood stasis, rheumatic bone disease, applied to medical preparations containing active ingredients, bone diseases, drug combinations, etc., can solve problems such as gastric irritation, liver and kidney functions, and improve safety, Improvement of extract quality and effect of improving microcirculation in mice

Active Publication Date: 2014-09-10
通化斯威堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In prior art, the medicine that treats waist, leg, shoulder, neck joint pain caused by rheumatic strain, hyperosteogeny etc. to cause microcirculation disorder is mostly oral preparations, taking too much not only has influence on liver and kidney function, but also on Stomach is also very irritating
External application of Chinese herbal medicines and appropriate application methods can also improve microcirculation.

Method used

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  • External use drug capable of improving microcirculation, clearing and activating channels and collaterals, promoting blood circulation removing stasis and treating rheumatism bone diseases and preparation method thereof
  • External use drug capable of improving microcirculation, clearing and activating channels and collaterals, promoting blood circulation removing stasis and treating rheumatism bone diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A medicine for external use capable of improving microcirculation, dredging meridians and collaterals, promoting blood circulation and removing blood stasis, and treating rheumatic bone disease, which is made into granules of the following raw materials in parts by weight: 10 parts of Passepartout, 8 parts of Fangfeng, and 8 parts of Atractylodes atractylodes , 8 parts of Angelica, 8 parts of Artemisia argyi, 8 parts of Duhuo, 8 parts of Spatholobus, 10 parts of Polygonum cuspidatum, 10 parts of Epimedium, 10 parts of Eucommia, 4 parts of Guizhi, 4 parts of Safflower, and 4 parts of Sappan.

[0030] Preparation method: Take 4 traditional Chinese medicinal materials of Fangfeng, Duhuo, Epimedium, and Sappan, and cut them into 10-15mm sections. Mix it with the above 4 traditional Chinese medicinal materials, put it in a heat reflux extraction tank, add water to soak for 1 hour, heat reflux extraction for 5 hours, concentrate to a specific gravity of 1.15-1.20, dry at 80°C,...

Embodiment 2

[0032] A medicine for external use capable of improving microcirculation, dredging meridians and collaterals, promoting blood circulation and removing blood stasis, and treating rheumatic bone disease, which is made into granules of the following raw materials in parts by weight: 7 parts of Passepartout, 9 parts of Fangfeng, and 9 parts of Atractylodes , 9 parts of Angelica, 9 parts of Artemisia argyi, 9 parts of Duhuo, 9 parts of Caulis Spatholobus, 8 parts of Polygonum cuspidatum, 8 parts of Epimedium, 8 parts of Eucommia, 5 parts of Guizhi, 5 parts of Safflower, and 5 parts of Sappan.

[0033] Preparation method: Take 4 traditional Chinese medicinal materials of Fangfeng, Duhuo, Epimedium, and Sappan, and cut them into 10-15mm sections. Mix it with the above 4 traditional Chinese medicinal materials, put it in a heat reflux extraction tank, add 5 times the amount of water to soak for 1 hour, heat reflux for 5 hours, concentrate to a specific gravity of 1.15-1.20, dry at 80 °...

experiment example 1

[0035] Process selection orthogonal experiment results are:

[0036] factor level table

[0037]

[0038] Orthogonal experiment design table and results

[0039]

[0040] The optimal experimental conditions selected from the above test results are: the extraction time of the medicinal materials is 5 hours, and the amount of the solvent is 5 times that of the medicinal materials.

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PUM

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Abstract

The invention relates to an external use drug or health product, in particular to an external use drug capable of improving microcirculation, clearing and activating channels and collaterals, promoting blood circulation removing stasis and treating rheumatism bone diseases and a preparation method of the external use drug. The method comprises the steps of taking and cutting the four traditional Chinese medicinal materials of saposhnicovia divaricate, radix angelicae pubescentis, longspur epimedium and caesalpinia sappan into segments with the length ranging from 10 mm to 15 mm, mixing liquidambar formosana hance, rhizoma atractylodis, angelica sinensis, folium artemisiae argyi, suberect spatholobus stems, polygonum cuspidatum, eucommia ulmoides, cassia twig and flos carthami with the four traditional Chinese medicinal materials, placing the mixture into a heat reflux extraction tank, adding water for soaking for 1 h, conducting heating reflux extraction for 5 h, concentrating the mixture to until the density ranges from 1.15 to 1.20, conducting drying at the temperature of 80 DEG C, smashing the mixture into fine powder, placing the fine powder into a granulator for granulation, drying the wet granulates, controlling the temperature to range from 40 DEG C to 50 DEG C for 2 min to 3 min, placing the dried granulates into an oscillating granular to be granulated with a 16-mesh screen cloth, and packaging the granulates to obtain the external use drug. The external use drug has the health care function, improves microcirculation, is applicable to people who have waist, leg, shoulder and neck joint pains caused by rheumatism strains and have microcirculation disturbance caused by hyperostosis.

Description

Technical field [0001] The present invention involves an external drug, health supplies and preparation methods. Specifically, it is a kind of topical drugs and preparation methods that can improve microcirculation, pass through Shu Luo, promote blood circulation and stasis, and treat rheumatism.Soak leg granules). Background technique [0002] Among the existing technologies, the treatment of waist, legs, shoulders, neck joint pains, and bone hyperplasia caused by rheumatism damage caused by microcirculation disorders is mostly oral preparations.The stomach also has great irritation.The external use and appropriate method of use of Chinese medicinal materials also achieved no reports that improved the microcirculation. Invention content [0003] The purpose of the present invention is to provide an topical drug and preparation method that can improve microcirculation, pass through the meridian, promote blood circulation and stasis, and treat rheumatism. [0004] The technical s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K9/16A61P9/14A61P29/00A61P19/02A61P19/08
CPCA61K9/0014A61K9/1617A61K36/185A61K36/232A61K36/238A61K36/282A61K36/284A61K36/286A61K36/296A61K36/46A61K36/48A61K36/486A61K36/54A61K36/704A61K2236/331A61K2236/51A61K2300/00
Inventor 杜明珠
Owner 通化斯威堂医药科技有限公司
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