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Systems and methods for visualizing ablated tissue

Tissue, vascular technology, in the field of systems and methods for visualizing ablated tissue

Active Publication Date: 2017-02-22
GEORGE WASHINGTON UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] All of these strategies use surrogates to predict the region of the gap and none have real-time direct visualization techniques like ours

Method used

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  • Systems and methods for visualizing ablated tissue
  • Systems and methods for visualizing ablated tissue
  • Systems and methods for visualizing ablated tissue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0109] experiment procedure

[0110] Experiments were performed using animal hearts to compare the validity of NADH-recorded imaging using the present disclosure with triphenyltetrazolium chloride (TTC) staining comparison. As will be described in more detail below, imaging using NADH recordings performed as well as TTC staining. Importantly, it is done in living tissue and does not require any additional processing time or the use of dyes to achieve the same performance.

[0111] animal process

[0112] Ex vivo experiments were performed using dissected bloodless hearts of rats (200-300 g Sprague-Dawley, n=8) and rabbits (2.5-3.5 Kg New Zealand White, n=3). Animals were heparinized and anesthetized using standard procedures. The heart was then dissected, the aorta was cannulated and infused with oxygenated buffered Tyrode's solution at room temperature Langendorff at constant pressure (50 mmHg). The heart was placed on top of a grounding pad and immersed in 37°C Tyrode'...

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PUM

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Abstract

Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprises: a catheter (1601) having a distal end and a proximal end; an inflatable balloon (1603) positioned near the distal end of the catheter (1601); and an optical A housing (1803) extending from the distal end of the catheter (1601) into the balloon (1603), the optical housing (1803) configured to allow a light source for illuminating tissue external to the balloon (1603) ( 1805) and a camera (1804) for imaging the irradiated tissue are located inside the balloon (1603).

Description

[0001] related application [0002] This application claims the benefit of and priority to U.S. Application No. 13 / 624,902, filed September 22, 2012, which is a continuation-in-part of U.S. Application No. 13 / 624,899, filed September 22, 2012, and claims 2011 The benefit and priority of US Provisional Application No. 61 / 537,798, filed September 22, and the entirety of which applications are hereby incorporated by reference. [0003] statement of government support [0004] This invention was made with Government support under Grant / Contract No. R01HL095828 awarded by the National Institutes of Health. The government has certain rights in this invention. technical field [0005] Embodiments disclosed herein relate to methods and systems for ablation and visualization of tissue. Background technique [0006] Exemplary embodiments relate to techniques used during the treatment of Atrial Fibrillation (AF). Atrial fibrillation is the most common sustained cardiac arrhythmia, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B1/06A61M25/10
CPCA61B5/0084A61B5/004A61B2018/0022A61B2018/0212A61B2034/301A61B90/30A61B90/361A61B2090/365A61B1/00186A61B1/05A61B1/0676A61B1/0684A61B1/043A61B1/00082A61B1/0638A61B90/35A61B18/1492Y02A90/10A61B17/00A61B18/12A61B5/0044A61B5/1459A61B5/14546A61B1/00045A61B5/14503A61B1/00009A61B5/6853A61B18/00
Inventor 奥马尔·阿米拉纳肯尼斯·C·阿姆斯特朗马修·W·凯马可·A·梅卡德尔特伦斯·J·兰斯伯里纳里内·萨尔瓦扬
Owner GEORGE WASHINGTON UNIVERSITY