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Ophthalmic Blumea balsamifera oil preparation and preparation method thereof

A technology of Aina sesame oil and ophthalmic preparations, which is applied in the field of medicine, can solve the problems such as Aina fragrance that has not yet been seen, and achieve good sterilization and anti-inflammatory effects, good conjunctivitis, and good stability

Active Publication Date: 2014-11-05
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no ophthalmic preparation product of Ainaxiang

Method used

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  • Ophthalmic Blumea balsamifera oil preparation and preparation method thereof
  • Ophthalmic Blumea balsamifera oil preparation and preparation method thereof
  • Ophthalmic Blumea balsamifera oil preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] To prepare Aina balm eye drops:

[0032] Add 10g of poloxamer to 600ml of water for injection to swell; in addition, weigh 2.5g of sodium oxide, 12g of boric acid, 1.5g of borax, 0.3g of ethylparaben, 1g of sodium sulfite, 1g of EDTA, add 300ml of water for injection, stir to dissolve, Then add 1.5 g of Aina sesame oil, stir to make it dissolve, and adjust the pH value to 7.0; add the mixed solution containing the main drug into the fully swelled poloxamer solution, add water to 1000 ml, stir evenly, filter with 0.1% activated carbon, Then pass through a 0.22 μm microporous filter membrane for fine filtration, aseptically dispense into eye drop bottles, and pack to obtain the product.

Embodiment 2

[0034] To prepare Aina balm eye drops:

[0035] Add 80g of poloxamer to 600ml of water for injection to swell; in addition, weigh 4g of sodium oxide, 1.5g of sodium dihydrogen phosphate, 7.5g of disodium hydrogen phosphate, 1g of phenylethyl alcohol, 1g of sodium sulfite, and 1g of EDTA, add 300ml of water for injection, and stir to make Dissolve, then add 10g of Aina sesame oil, stir to dissolve, and adjust the pH value to 6.0; add the mixed solution containing the main drug into the fully swollen poloxamer solution, add water to 1000ml, stir evenly, and filter with 0.05% activated carbon , and then filtered through a 0.22μm microporous membrane, aseptically dispensed into eye drop bottles, and packaged to obtain the product.

Embodiment 3

[0037] To prepare Aina balm eye drops:

[0038] Add 40g of poloxamer to 600ml of water for injection to swell; in addition, weigh 3g of sodium oxide, 2g of sodium dihydrogen phosphate, 8.5g of disodium hydrogen phosphate, 1g of benzalkonium bromide, 1g of sodium sulfite, 1g of EDTA, add 300ml of water for injection, and stir Make it dissolve, then add 5g of Aina sesame oil, stir to make it dissolve, and adjust the pH value to 8.0; add the mixed solution containing the main drug into the fully swollen poloxamer solution, add water to 1000ml, stir evenly, and add 0.2% activated carbon Filter, then pass through a 0.22μm microporous membrane for fine filtration, aseptically dispense into eye drop bottles, and pack to obtain the product.

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PUM

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Abstract

The invention discloses an ophthalmic Blumea balsamifera oil preparation and a preparation method thereof. The ophthalmic preparation comprises eye drops, an eye ointment, an ophthalmic liposome and clathrate compound eye drops. The ophthalmic Blumea balsamifera oil preparation is prepared by adopting Blumea balsamifera oil as an active effective component and adding medicinal auxiliary materials for the ophthalmic preparation, and concretely comprises 0.15-1wt% of Blumea balsamifera oil, and the balance the auxiliary materials for the ophthalmic preparation. The ophthalmic preparation can effectively treat conjunctivitis, and tests prove that the ophthalmic preparation has the advantages of no irritable inflammation reaction, safe and stable use and definite therapeutic effects.

Description

technical field [0001] The invention relates to an ophthalmic preparation of ainascent oil and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Conjunctivitis is a common disease in ophthalmology, and it is a general term for the inflammatory reaction of conjunctival tissue under the influence of external factors and body's own factors. Since most of the conjunctiva is in direct contact with the outside world, it is easily stimulated by infectious (such as bacteria, viruses, and chlamydia, etc.) and non-infectious factors (trauma, chemical substances, and physical factors, etc.) in the surrounding environment. Lymphatic tissue is abundant, and it is easy to be sensitized by self and external antigens. [0003] Most of the drug eye drops currently used for treatment are western medicine preparations, such as acute viral conjunctivitis, steroid (cortisone) eye drops can be ordered to alleviate the condition; bacterial c...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K9/08A61K9/127A61K9/06A61P27/02A61P31/00
Inventor 钱一鑫康冀川王鲁
Owner GUIZHOU UNIV
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