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Water-soluble bone wax, and preparation method

A water-soluble, bone wax technology, used in medical science, bandages, absorbent pads, etc., can solve the problems of surrounding tissue damage, long-term retention, poor adhesion, etc., achieve no irritating inflammatory response, and facilitate growth and healing. , increase the effect of dissolution and discharge

Inactive Publication Date: 2007-12-26
JIAAN MEDICINES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of the bone wax composition thus prepared is that the wax has poor adhesion at room temperature and is highly brittle.
In addition, the developed paraffin-based bone wax cannot be absorbed by the body, so it will remain in the application site for a long time
Therefore, when these waxes are used in the body, they can cause infection and cause an inflammatory response, destroying surrounding tissue and affecting bone regrowth

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1. contains the preparation of the water-soluble bone wax of the Tween of 69 weight % polyoxyethylene and polyoxypropylene copolymer and 10 weight %

[0032] 69 g of PLURONIC from BASF  Copolymer, 10 grams of Tween 60, and 21 grams of hemostatic agent water-soluble chitosan were put into a flask, mixed thoroughly by mechanical stirring, and then the resulting mixture was heated to about 70°C to 120°C until the mixture appeared as a liquid shape. Then, the mechanically stirred mixture was immediately placed in a low temperature of -10°C to -150°C for about 30 minutes, so that it was rapidly frozen and crystallized. After crystallization, the temperature of the system was raised to room temperature to allow the product to take shape. Finally, the resulting product is sub-packaged, sealed, and sterilized by high pressure or ∝ rays.

Embodiment 2

[0033] Example 2. Preparation of water-soluble bone wax containing 99.5% by weight of polyoxyethylene and polyoxypropylene copolymer and 0.5% by weight of Tween

[0034] 99.5 g of PLURONIC from BASF  The copolymer and 0.5 g of Tween 80 were placed in a flask, thoroughly mixed by mechanical stirring, and the resulting mixture was then heated to about 70°C to 120°C until the mixture became liquid. Then, the mechanically stirred mixture was immediately placed in a low temperature of -10°C to -150°C for about 30 minutes, so that it was rapidly frozen and crystallized. After crystallization, the temperature of the system was raised to room temperature to allow the product to take shape. Finally, the obtained product is sub-packaged, sealed, and sterilized by high pressure or gamma rays.

Embodiment 3

[0035] Example 3. Preparation of water-soluble bone wax containing 99.5% by weight of polyoxyethylene and polyoxypropylene copolymer and 0.1% by weight of Tween

[0036] 99.5 g of PLURONIC from BASF  The copolymer was put into a flask with 0.1 g of Tween 80 and 0.4 BMP-2, thoroughly mixed by mechanical stirring, and then the resulting mixture was heated to about 70° C. to 120° C. until the mixture became liquid. Then, the mechanically stirred mixture was immediately placed in a low temperature of -10°C to -150°C for about 30 minutes, so that it was rapidly frozen and crystallized. After crystallization, the temperature of the system was raised to room temperature to allow the product to take shape. Finally, the obtained product is sub-packaged, sealed, and sterilized by high pressure or gamma rays.

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PUM

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Abstract

The present invention relates to a water-bath bone wax. It includes one or two copolymers obtained by making polyoxyethlene and polyoxypropylene undergo the process of copolymerization reaction and emulsifying agent anhydrosorbitol aliphatic ester. Said invention also relates to a kit including the invented water-bath bone wax and a preparation method of said water-bath bone wax.

Description

technical field [0001] The invention discloses a bone wax. Specifically, the invention discloses a "water-soluble" bone hemostatic material used in orthopedics or surgery, that is, water-soluble bone wax. The invention also discloses a preparation method of the bone wax. Background technique [0002] During many surgical procedures and trauma, bones bleed. In the control of bone bleeding or hemostasis, people researched and developed bone wax applied to bone as a mechanical barrier, which can effectively stop bleeding. [0003] Bone wax used in surgery is usually prepared from beeswax by mixing them with water-insoluble hydrocarbons and vegetable oils. A disadvantage of the bone wax compositions thus prepared is that the wax is poorly bonded and brittle at room temperature. In addition, the developed paraffin-based bone wax cannot be absorbed by the body, so it will remain at the application site for a long time. Therefore, when these waxes are used in the body, they ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/24A61L15/62
Inventor 顾汉卿张青丽
Owner JIAAN MEDICINES DEV
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