Application of sulfated codonopsis pilosul polysaccharide to preparation of herpes simplex virus type I resistance medicament and preparation method of herpes simplex virus type I resistance medicament
A technology of herpes simplex virus and Codonopsis polysaccharide, applied in the field of pharmacy
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Embodiment 1
[0085] Embodiment 1 of the present invention: the preparation method of Codonopsis polysaccharide sulfate ester, specifically as follows:
[0086] 1) Extraction of Codonopsis polysaccharide
[0087] Decoction with water - alcohol precipitation method. Take 1000 g of Dangshen decoction pieces, crush them, put them in a Soxhlet extractor, heat and reflux with 80% ethanol for 3 times to degrease, add 10 times the amount of water to decoct the dregs for 3 times, the first time for 3 hours, the second time for 2 hours, and the second time for 2 hours. 3 times for 1 h; the residue was filtered with suction, and the filtrates were combined for 3 times and then concentrated. Add 95% ethanol to the concentrated solution until the ethanol content is 80%, put it in a refrigerator at 4 °C for 12 h, centrifuge at 3000 r / min, collect the precipitated part, dry it in vacuum, redissolve, add 95% ethanol until the ethanol content is 80% %, centrifuge, collect the precipitate, freeze-dry, and...
Embodiment 2
[0097] Embodiment 2 of the present invention: Take Codonopsis Polysaccharide Sulfate 3g , medical starch 75 g, microcrystalline cellulose 20 g, the medicinal starch is dried first, passed through a 120 mesh sieve, and then mixed with Codonopsis polysaccharide sulfate , microcrystalline cellulose are mixed, cross 120 mesh sieves twice, fill in the hard capsule, make 1000 capsules of the present invention. Each hard capsule contains the main ingredient 0.3 mg.
Embodiment 3
[0098] Embodiment 3 of the present invention: Take Codonopsis Polysaccharide Sulfate 3g , 6 g of hypromellose, 10 g of sodium starch glycolate, 8 g of microcrystalline cellulose, 115 g of lactose, 50 g of starch, and 1 g of magnesium stearate; fully mix the main ingredient and auxiliary materials and put them into a high-speed mixer, spray with appropriate amount of water, Whole grains, the water content is controlled at 3~4%, and then pressed into tablets to make 1000 tablets, coated with film. Each capsule contains main ingredients 0.3 mg.
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