Preparation method of tulathromycin powder for treating colibacillosis

Abstract

The invention relates to a preparation method of tulathromycin powder for treating colibacillosis. The preparation method comprises the following steps: adding 1-20% of tulathromycin phosphorate and 0-0.5mmol / g of a cosolvent to a carrier; and evenly mixing, drying, and screening the raw materials by an 80-mesh sieve. The tulathromycin disclosed by the invention is quickly absorbed after drug administration, and has the advantages of high bioavailability, long half-life period, lasting pharmacological effect and relatively high safety, and is suitable for the requirements of livestock husbandry development.

Description

technical field

[0001] The invention belongs to the field of medicine and relates to a telamycin soluble powder for treating colibacillosis. Background technique

[0002] The application of antibacterial drugs to treat colibacillosis is still the main treatment measure at present: commonly used antibiotics, quinolones, sulfonamides, furans and other antibacterial and anti-inflammatory drugs have certain curative effects on colibacillosis. However, due to the long-term or high-dose abuse of antibacterial drugs in many chicken farms, especially the repeated prophylaxis of high concentrations has induced the emergence of many resistant strains of Escherichia coli. Make a lot of originally sensitive medicines but can't achieve the effect of treatment.

[0003] Colibacillosis is a common and frequently-occurring disease caused by Escherichia coli. Including Escherichia coli peritonitis, salpingitis, omphalitis, synovitis, air sacitis, granuloma, ophthalmia and other diseases, w...

Examples

Embodiment 1

[0013] 2% w / w as Tyramycin, Tyramycin Soluble Powder Preparation:

[0014] a. 2% w / w based on telamycin, telamycin tartrate

[0015] b. Carrier: dextrin 200g, sucrose up to 1000g.

[0016] Preparation steps: take sucrose and pulverize it, mix it with 31.17 g of telamycin tartrate and dextrin, dry it, and pass it through an 80-mesh sieve to obtain the product.

Embodiment 2

[0018] 5% w / w as Tyramycin, Tyramycin Soluble Powder Preparation:

[0019] a. 5% w / w based on telamycin, telamycin phosphate

[0020] b, glucose powder to 1000g.

[0021] Preparation steps: take 68.36 g of telamycin phosphate and glucose powder, mix evenly, pulverize, and pass through an 80-mesh sieve to obtain the product.

technical field

[0001] The invention belongs to the field of medicine and relates to a telamycin soluble powder for treating colibacillosis. Background technique

[0002] The application of antibacterial drugs to treat colibacillosis is still the main treatment measure at present: commonly used antibiotics, quinolones, sulfonamides, furans and other antibacterial and anti-inflammatory drugs have certain curative effects on colibacillosis. However, due to the long-term or high-dose abuse of antibacterial drugs in many chicken farms, especially the repeated prophylaxis of high concentrations has induced the emergence of many resistant strains of Escherichia coli. Make a lot of originally sensitive medicines but can't achieve the effect of treatment.

[0003] Colibacillosis is a common and frequently-occurring disease caused by Escherichia coli. Including Escherichia coli peritonitis, salpingitis, omphalitis, synovitis, air sacitis, granuloma, ophthalmia and other diseases, w...

Examples

Embodiment 1

[0013] 2% w / w as Tyramycin, Tyramycin Soluble Powder Preparation:

[0014] a. 2% w / w based on telamycin, telamycin tartrate

[0015] b. Carrier: dextrin 200g, sucrose up to 1000g.

[0016] Preparation steps: take sucrose and pulverize it, mix it with 31.17 g of telamycin tartrate and dextrin, dry it, and pass it through an 80-mesh sieve to obtain the product.

Embodiment 2

[0018] 5% w / w as Tyramycin, Tyramycin Soluble Powder Preparation:

[0019] a. 5% w / w based on telamycin, telamycin phosphate

[0020] b, glucose powder to 1000g.

[0021] Preparation steps: take 68.36 g of telamycin phosphate and glucose powder, mix evenly, pulverize, and pass through an 80-mesh sieve to obtain the product.