Propyl p-hydroxybenzoate and hydroxypropyl-beta-cyclodextrin supermolecular inclusion complex and preparation method and using method of inclusion complex

Abstract

The invention discloses a supermolecular inclusion complex of a mildew-proof antibacterial agent, propyl p-hydroxybenzoate, and hydroxypropyl-beta-cyclodextrin and a preparation method and a using method of the inclusion complex. The inclusion complex comprises propyl p-hydroxybenzoate and hydroxypropyl-beta-cyclodextrin, wherein a weight ratio of propyl p-hydroxybenzoate to hydroxypropyl-beta-cyclodextrin is less than or equal to 1:8. Propyl p-hydroxybenzoate has excellent water solubility, the water solubility of propyl p-hydroxybenzoate is changed from insolubility to easy solubility, the problem that propyl p-hydroxybenzoate is difficult to apply to and operate in an aqueous solution is solved, and propyl p-hydroxybenzoate can be applied under the high-concentration condition; high usability of propyl p-hydroxybenzoate is guaranteed, and propyl p-hydroxybenzoate can be directly added into an aqueous solution or can be directly dissolved in water with other components for use; due to protection of hydroxypropyl-beta-cyclodextrin, possible chemical compatibility and degradation ineffectiveness of propyl p-hydroxybenzoate with other components in the solution are overcome, and high stability is guaranteed; moreover, the antibacterial and antimicrobial effects and ranges of propyl p-hydroxybenzoate are kept invariable by virtue of the supermolecular inclusion complex of propyl p-hydroxybenzoate and hydroxypropyl-beta-cyclodextrin.

Description

Technical field [0001] The invention relates to the field of mildew and antibacterial, in particular to a hydroxypropyl-β-cyclodextrin supermolecular inclusion compound of hydroxypropyl benzoate, a preparation method and a use method. Background technique [0002] Propyl p-hydroxybenzoate is also called methyl p-hydroxybenzoate and methyl 4-hydroxybenzoate. This product is white needle-like crystals or colorless crystals. It is easily soluble in organic solvents such as ethanol, ether and acetone, and is extremely Slightly soluble, with a melting point of 96-97°C, it is an internationally recognized broad-spectrum, high-efficiency and low-toxic preservative. The United States, Europe, Japan, Canada, South Korea, Russia and other countries allow propyl hydroxybenzoate to be used in food, cosmetics, For applications in the fields of medicine and feed, China's GB2760 also stipulates that sodium propyl p-hydroxybenzoate can be used as a food preservative. [0003] Because of its pheno...

AI Technical Summary

Problems solved by technology

However, this product is very slightly soluble in water. When used in water-based solutions for anticorrosion, it is necessary to use organic solvents such as ethanol to enhance its solubility in water, and organic solvents are not easy to remove from aqueous solutions. Propyl p-hydroxybenzoate gradually precipitates from the solution and loses its antiseptic effect, which affects the use and antibacterial and antibacterial efficacy of propyl p-hydroxybenzoate in aqueous solution, and affects the convenience and safety of use and operation

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