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Hydroxypropyl-beta-cyclodextrin supermolecule clathrate compound of butyl p-hydroxybenzoate, and preparing method and using method thereof

A technology of butyl hydroxybenzoate and hydroxypropyl, which is applied in the field of supramolecular inclusion compound of hydroxypropyl-β-cyclodextrin, can solve the problem of affecting the use of butyl hydroxybenzoate, antibacterial and antibacterial efficacy, and affecting convenience , safety, organic solvents are not easy to remove, etc., to solve the problems of difficult application and operation, low toxicity, antibacterial and antibacterial effects, large solubility and chemical stability

Inactive Publication Date: 2014-11-26
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this product is very slightly soluble in water. When used in water-based solutions for anticorrosion, it is necessary to use organic solvents such as ethanol to enhance its solubility in water, and organic solvents are not easy to remove from aqueous solutions. Butyl p-hydroxybenzoate gradually precipitates from the solution and loses its antiseptic effect, which affects the use and antibacterial and antibacterial efficacy of butyl p-hydroxybenzoate in aqueous solution, and affects the convenience and safety of use and operation

Method used

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  • Hydroxypropyl-beta-cyclodextrin supermolecule clathrate compound of butyl p-hydroxybenzoate, and preparing method and using method thereof
  • Hydroxypropyl-beta-cyclodextrin supermolecule clathrate compound of butyl p-hydroxybenzoate, and preparing method and using method thereof
  • Hydroxypropyl-beta-cyclodextrin supermolecule clathrate compound of butyl p-hydroxybenzoate, and preparing method and using method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The hydroxypropyl-β-cyclodextrin supramolecular inclusion complex of butyl p-hydroxybenzoate in this embodiment, by weight, butyl p-hydroxybenzoate:hydroxypropyl-β-cyclodextrin=1:10 .

[0031] In this example, the hydroxypropyl-β-cyclodextrin is 2-hydroxypropyl-β-cyclodextrin, and the hydroxypropyl derivatives of other β-cyclodextrins with similar physical and chemical properties (3-hydroxypropyl Base-β-cyclodextrin) instead of 2-hydroxypropyl-β-cyclodextrin has no significant effect on the performance of the product.

[0032] The preparation method of the hydroxypropyl-beta-cyclodextrin supramolecular inclusion complex of butyl p-hydroxybenzoate in this embodiment, the hydroxypropyl-beta-cyclodextrin is mixed with the hydroxypropyl-beta-cyclodextrin by weight ratio Dextrin: water=0.5 is dissolved in the water that temperature is 80 ℃ and adds the butyl p-hydroxybenzoate of setting weight ratio, then constantly stirs under heating or insulation until butyl p-hydroxyben...

Embodiment 2

[0036] The hydroxypropyl-β-cyclodextrin supramolecular inclusion complex of butyl p-hydroxybenzoate in this embodiment, by weight, butyl p-hydroxybenzoate:hydroxypropyl-β-cyclodextrin=1:20 .

[0037] In this example, the hydroxypropyl-β-cyclodextrin is 3-hydroxypropyl-β-cyclodextrin, and the hydroxypropyl derivatives of other β-cyclodextrins with similar physical and chemical properties (2-hydroxypropyl 3-hydroxypropyl-β-cyclodextrin) instead of 3-hydroxypropyl-β-cyclodextrin has no obvious effect on the performance of the product.

[0038] The preparation method of the hydroxypropyl-beta-cyclodextrin supramolecular inclusion complex of butyl p-hydroxybenzoate in this embodiment, the hydroxypropyl-beta-cyclodextrin is mixed with the hydroxypropyl-beta-cyclodextrin by weight ratio Dextrin: water=0.3 is dissolved in the water of 70 ℃ and adds the butyl p-hydroxybenzoate of setting weight ratio after being dissolved in water, then constantly stirs under heating or insulation until...

Embodiment 3

[0042] The hydroxypropyl-β-cyclodextrin supramolecular inclusion complex of butyl p-hydroxybenzoate in this embodiment, by weight, butyl p-hydroxybenzoate:hydroxypropyl-β-cyclodextrin=1:30 .

[0043] In this example, the hydroxypropyl-β-cyclodextrin is 3-hydroxypropyl-β-cyclodextrin, and the hydroxypropyl derivatives of other β-cyclodextrins with similar physical and chemical properties (2-hydroxypropyl 3-hydroxypropyl-β-cyclodextrin) instead of 3-hydroxypropyl-β-cyclodextrin has no obvious effect on the performance of the product.

[0044] The preparation method of the hydroxypropyl-beta-cyclodextrin supramolecular inclusion complex of butyl p-hydroxybenzoate in this embodiment, the hydroxypropyl-beta-cyclodextrin is mixed with the hydroxypropyl-beta-cyclodextrin by weight ratio Dextrin: water=1, be dissolved in the water that temperature is 65 ℃ and add the butyl p-hydroxybenzoate of setting weight ratio, then constantly stir under heating or insulation until butyl p-hydrox...

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Abstract

A hydroxypropyl-beta-cyclodextrin supermolecule clathrate (inclusion) compound of butyl p-hydroxybenzoate, which is a mildew-resistant and anti-bacterial medicine, and a preparing method and a using method thereof are disclosed. The clathrate (inclusion) compound comprises the butyl p-hydroxybenzoate and hydroxypropyl-beta-cyclodextrin in a weight ratio not less than 1:7.5. The butyl p-hydroxybenzoate obtains good water solubility and the water solubility of the butyl p-hydroxybenzoate turns from insolubility to easy solubility, and therefore the problem that an aqueous butyl p-hydroxybenzoate solution is not liable to apply or operate is overcome, the butyl p-hydroxybenzoate can be applied in a circumstance of high concentrations, and the butyl p-hydroxybenzoate obtains good usability and can be directly added into an aqueous solution or can be directly dissolved with water together with other components. By protection of the hydroxypropyl-beta-cyclodextrin, possible chemical compatibility and degradation invalidation problems with other components in the solution are overcome, so that good stability is achieved. The supermolecule clathrate (inclusion) compound of the hydroxypropyl-beta-cyclodextrin and the butyl p-hydroxybenzoate maintains mildew-resistant and anti-bacterial functions and maintains the range unchanged.

Description

technical field [0001] The invention relates to the antifungal and antibacterial field, in particular to a hydroxypropyl-β-cyclodextrin supramolecular inclusion compound of butyl p-hydroxybenzoate, a preparation method and a use method. Background technique [0002] Butyl p-hydroxybenzoate is also known as methyl p-hydroxybenzoin and methyl 4-hydroxybenzoate. This product is white needle-like crystal or colorless crystal. It is easily soluble in organic solvents such as ethanol, ether, and acetone. Slightly soluble, with a melting point of 68-69°C, it is an internationally recognized broad-spectrum, high-efficiency, and low-toxic preservative. The United States, Europe, Japan, Canada, South Korea, Russia and other countries have allowed butyl p-hydroxybenzoate to be used in food, cosmetics, For applications in the fields of medicine and feed, my country's GB2760 also stipulates that butyl p-hydroxybenzoate sodium salt can be used as a food preservative. [0003] Due to its ph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/40A01N25/10A01P1/00A01P3/00
Inventor 王章阳赵映兰石英刘松青夏培元
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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