Preparation method of polymer-embedded hydrophobic anti-tumor drug nano-composite microsphere

Abstract

The invention belongs to the crossing technical field of chemical engineering, pharmaceutical engineering and material engineering and relates to preparation methods of polymer carried drugs, particularly to a method of preparing a polymer-embedded hydrophobic anti-tumor drug nano-composite microsphere through in-situ miniemulsion polymerization. The method comprises dissolving hydrophobic anti-tumor drugs into acrylate monomers, and then adding the mixture slowly into water solution containing emulsifier; performing ultrasonic emulsification on the mixed water solution through an ultrasonic cell crusher to obtain miniemulsion, and then performing in-situ miniemulsion polymerization to obtain the embedded hydrophobic anti-tumor drug nano-composite microsphere. According to the preparation method of the polymer-embedded hydrophobic anti-tumor drug nano-composite microsphere, the hydrophobic anti-tumor drug is embedded through a single polymerization step, so that drug molecules can be distributed evenly, and meanwhile, high drug carrying capacity and high encapsulating rate can be obtained; no organic solvent is utilized during the reactions, so that environmental pollution and secondary damage to human can be avoided. The method of preparing the polymer-embedded hydrophobic anti-tumor drug nano-composite microsphere has a wide application prospect.

Description

technical field [0001] The invention belongs to the interdisciplinary technical fields of chemical engineering, pharmaceutical engineering and material engineering, and in particular relates to a preparation method for polymer-loaded drugs, in particular to a nanocomposite microparticle prepared by using in-situ miniemulsion polymerization to embed hydrophobic anti-tumor drugs in polymers. Ball preparation method. Background technique [0002] With the increasing incidence of tumors, the delivery system of anticancer drugs has attracted widespread attention. As we all know, the toxic and side effects of anti-tumor drugs are very serious. When they are administered directly to the human body, they will not only kill tumor cells but also damage healthy cells. Therefore, drug carriers are needed to embed the drugs and modify the surface of drug carriers. , to endow the drug with slow release and targeting to tumor cells, so that the embedded drug can be delivered to the tumor ...

AI Technical Summary

Problems solved by technology

[0004] Using the above method to prepare composite microspheres or microcapsules for embedding hydrophobic anti-tumor drugs, it is usually necessary to synthesize polymer macromolecular materials first, and then mix them with drugs through a certain process, which basically belongs to the physical mixing between macromolecular materials and drug molecules. , the drug is unevenly dispersed in microspheres or microcapsules, the coating rate is low, and the drug is prone to agglomeration, which affects the therapeutic effect

In addition, this method is complicated in process, and organic solvents are often used in the embedding process, which is easy to cause environmental pollution and cause secondary damage to the human body. Therefore, it is necessary to seek a new method of embedding anti-tumor drugs to overcome the above shortcomings. A new idea in the field of drug coating

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