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Traditional Chinese medicine composition, and preparation method and application thereof

The technology of a composition and a traditional Chinese medicine, applied in the field of medicine, can solve the problems such as the inability to improve the cure rate of patients with acute upper respiratory tract infection, and achieve the effects of convenient quality control, reasonable production process and fast drug testing speed.

Inactive Publication Date: 2015-01-14
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is still a lack of mature drugs for the clinical treatment of acute upper respiratory tract infection, and the abuse of antibiotics is common. Studies have shown that antibiotic treatment cannot improve the cure rate of patients with acute upper respiratory tract infection

Method used

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  • Traditional Chinese medicine composition, and preparation method and application thereof
  • Traditional Chinese medicine composition, and preparation method and application thereof
  • Traditional Chinese medicine composition, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] a Forsythia 25kg, Bupleurum 25kg add 10 times the amount of water to reflux to extract volatile oil for 4 hours, collect forsythia and Bupleurum volatile oil for later use.

[0044] b Take β-cyclodextrin with 8 times the mass of volatile oil to make a saturated solution at 40°C.

[0045] c. Slowly drop the volatile oil into the β-cyclodextrin saturated solution, stir at constant temperature for 2 hours, filter, dry at 40°C at low temperature, pulverize, and pass through a 100-120 mesh sieve to obtain the β-cyclodextrin inclusion compound of the volatile oil.

[0046] d Extract the dregs of forsythia and bupleurum extract volatile oil with 20kg of licorice, 15kg of honeysuckle, 15kg of isatid root and add water to extract 3 times, the extraction time is 2 hours, filter, combine the decoction, filter, and extract volatile oil with forsythia and bupleurum The final water and liquid are combined, concentrated to a thick paste with a relative density of 1.05-1.20 at 50°C, sp...

Embodiment 2

[0048] a Forsythia 25kg, Bupleurum 25kg add 10 times the amount of water to reflux to extract volatile oil for 4 hours, collect forsythia and Bupleurum volatile oil for later use.

[0049] b Take β-cyclodextrin 10 times the mass of volatile oil to make a saturated solution at 40°C.

[0050] c. Slowly drop the volatile oil into the saturated solution of β-cyclodextrin, stir at constant temperature for 4 hours, filter, dry at 40°C, pulverize, and pass through a 100-120 mesh sieve to obtain the β-cyclodextrin inclusion compound of the volatile oil.

[0051] d Extract 20kg of licorice, 15kg of honeysuckle and 15kg of Radix Radix with water from the dregs of forsythia and bupleurum extracting volatile oil twice. The extraction time is 2 hours, filter, combine the decoction, filter, and extract volatile oil with forsythia and bupleurum The final water and liquid are combined, concentrated to a thick paste with a relative density of 1.05-1.20 at 50°C, spray-dried, pulverized into fine ...

Embodiment 3

[0053] a effervescent tablet formula of the present invention is made up of following components:

[0054]

[0055] b is prepared by dry granulation process, the specific preparation method is as follows: Take 1 / 2 amount of medicinal material extract, β-cyclodextrin inclusion complex, citric acid, stevioside, and sucrose, mix them evenly, pass through an 80-mesh sieve, and dry-press the granules , 20-60 mesh sieve to obtain acid granules; take 1 / 2 amount of medicinal material extract, β-cyclodextrin inclusion complex, sodium bicarbonate, stevioside, and sucrose, mix them evenly, pass through 80 mesh sieve, dry press granules, Sieve with 20-60 mesh to obtain alkali granules; mix the acid granules and alkali granules, add polyethylene glycol 6000, micropowder silica gel and mix well, then press into tablets, 2.5g / tablet, 1000 tablets in total, to obtain the foam of the present invention Teng tablets.

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Abstract

The invention belongs to the technical field of medicines, and discloses a traditional Chinese medicine composition, and a preparation method and application thereof. The traditional Chinese medicine composition comprises fructus forsythia, radix bupleuri, radix glycyrrhizae, flos lonicerae and radix isatidis, has substantial treating effect on acute upper respiratory tract infection and wind-heat cold, and is small in toxic and side effects and stable in curative effect. Also, the invention discloses a preparation containing the traditional Chinese medicine composition and a preparation method of the preparation. The technology is simple in operation, low in cost and controllable in quality, and is suitable for industrialized production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a traditional Chinese medicine composition containing extracts of forsythia, bupleurum, licorice, honeysuckle and isatis root five flavors of traditional Chinese medicines, a preparation method and application thereof, an oral preparation containing the composition and a preparation process thereof. Background technique [0002] Acute upper respiratory tract infection is a general term for acute inflammation from the external nares to the lower border of the cricoid cartilage, including the nasal cavity, pharynx or larynx. The onset is regardless of age, sex, occupation and region, and those with low immune function are susceptible. Usually the condition is mild, the course of the disease is short, and it can be cured spontaneously. However, due to the high incidence rate, it not only affects work and life, but also can sometimes be accompanied by serious complicatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K9/46A61P11/00
CPCA61K36/634A61K9/0007A61K9/205A61K36/195A61K36/233A61K36/315A61K36/355A61K36/484A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 白雪刘素香刘毅
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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