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A kind of prasugrel hydrobromide tablet and preparation method thereof

A kind of technology of hydrobromic acid and thunder tablet, which is applied in the field of medicine and achieves the effect of simple preparation process

Active Publication Date: 2018-05-11
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Documents in the prior art have not fundamentally solved the problem that prasugrel hydrobromide is easy to hydrolyze and oxidize

Method used

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  • A kind of prasugrel hydrobromide tablet and preparation method thereof
  • A kind of prasugrel hydrobromide tablet and preparation method thereof
  • A kind of prasugrel hydrobromide tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]

[0033] Preparation Process:

[0034] Dissolve prasugrel hydrobromide in macrogol glycerol oleate, add fumed silica for adsorption, and then mix with pregelatinized starch, lactose, sodium carboxymethyl starch, low-substituted hydroxypropyl The cellulose is mixed evenly, finally mixed with magnesium stearate and silicon dioxide, and compressed into tablets.

Embodiment 2

[0036]

[0037] Preparation Process:

[0038] Dissolve prasugrel hydrobromide in macrogol glycerol oleate, add fumed silica for adsorption, then mix evenly with pregelatinized starch and sodium carboxymethyl starch that have passed through a 100-mesh sieve, and finally mix with stearic acid Magnesium mixed, compressed into tablets.

Embodiment 3

[0040]

[0041] Preparation Process:

[0042] Dissolve prasugrel hydrobromide in macrogol glycerol oleate, add fumed silica for adsorption, then mix evenly with pregelatinized starch and sodium carboxymethyl starch that have passed through a 100-mesh sieve, and finally mix with stearic acid Magnesium mixed, compressed into tablets.

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Abstract

A prasugrel hydrobromide tablet, which is prepared by the following method: (1) prasugrel hydrobromide is dissolved in macrogolglycerol oleate, and then fumed silicon dioxide is added for adsorption; (2) The above mixture is mixed with pharmaceutically acceptable auxiliary materials and compressed into tablets. The obtained tablet has high stability and simple preparation process, and is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a prasugrel hydrobromide tablet and a preparation method thereof. Background technique [0002] Prasugrel was initially jointly developed by Eli Lilly, a large US biopharmaceutical company, and Japan's Daiichi Pharmaceutical Sankyo. It is an adenosine diphosphate (ADP) receptor antagonist. As an anticoagulant, it is a prodrug and has no activity itself. It is converted into its active metabolite R-138727 in the body; R-138727 Reduces the dependence on cytochrome P-450 enzymes, and rapidly, specifically, and irreversibly binds to the purine base receptors of platelet P2Y12, inhibiting the activity and aggregation of ADP-regulated platelets. Primarily used in patients requiring percutaneous coronary syndrome, including those requiring stenting. [0003] U.S. Patent 6693115B2 discloses the preparation of prasugrel hydrochloride and maleate. These two salt forms have ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/4365A61K47/14A61K47/04A61P7/02
Inventor 赵志全郝贵周崔祥祯刘延凤
Owner SHANDONG NEWTIME PHARMA