New application of sheep placenta extract in treatment of skin burn and trauma

A technology of sheep placenta and extract, applied in the field of medicine, can solve the problems such as unreported effect of sheep placenta on skin burn wounds, waste of resources, environmental pollution and the like

Inactive Publication Date: 2015-02-25
杨公明
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the processing amount of sheep placenta is only less than 3%, which causes a huge waste of resources and pollutes the environment
At present, although there are m

Method used

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  • New application of sheep placenta extract in treatment of skin burn and trauma
  • New application of sheep placenta extract in treatment of skin burn and trauma

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Embodiment Construction

[0014] Preparation of sheep placenta extract: take healthy fresh sheep placenta and add 5 times the total amount of normal saline (0°C), then make a slurry with liquid nitrogen, centrifuge at 4000rpm and centrifuge for 10min to obtain the supernatant, adjust its protein concentration to 50mg / mL, is sheep placenta extract;

[0015] Experimental animals: 100 healthy adult SD rats, half male and half male, weighing 180-200g, provided by Guangzhou Experimental Animal Center;

[0016] Experimental design: Divide the animals into a treatment group and a control group. Taking metal burns as an example, observe the recovery state of sheep placenta extract on the burned surface of rats. The treatment group is sprayed with sheep placenta extract every day, and its protein concentration is 100mg / mL ;

[0017] The production of the third-degree burn model of rats: use a small piece of asbestos cardboard 8cm×5cm, hollow out the middle, with an area of ​​4cm×3.5cm, take 100 rats, and divi...

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Abstract

The invention provides a new application of sheep placenta extract in treatment of skin burn and trauma. The sheep placenta extract has a treatment effect obviously better than that of common medicines, has excellent restoration effect and does not leave a scar, and newly born skin and hair are undifferentiated with the original skin and hair; main treatment effects of the sheep placenta extract comprise anti-inflammatory effect and tissue recovery effect; a main restoration mechanism is as follows: the sheep placenta extract can promote rapidly proliferation of macrophages and improve activities of the macrophages, the macrophages can secrete multiple bioactive substances and multiple enzymes, directly participates in an organism restoration process and eliminates necrotic fragments of tissues and cells and pathogens at a damaged part, and the bioactive substances and the enzymes have an important regulating effect and a good recovery effect on a skin burn and trauma healing process and is capable of effectively proliferating epidermic cells so that skin tissues can be quickly healed. Animal experiments further confirm that the sheep placenta extract has a treatment effect on a mouse burned by metal, and a related mechanism of the sheep placenta extract in treatment of the skin trauma is explained.

Description

technical field [0001] The invention relates to a new application of an animal placenta extract, in particular to a new application of a sheep placenta extract, which utilizes the sheep placenta extract for its anti-inflammatory effect and tissue healing effect in the treatment of skin burns, and belongs to the field of pharmaceuticals. Background technique [0002] With the rapid development of urban industry, transportation, construction, etc., as well as the occurrence of natural disasters and accidents, people are more and more likely to be injured, and the burns caused are becoming more and more complicated. Burns have become a hazard to human beings. One of the important injuries and diseases of health and life safety, burn is a kind of extremely complex traumatic disease caused by many factors such as physics, chemistry, radiation acting on the body. At present, there are many ways to treat wounds after human body burns, such as bandage therapy, exposure therapy, etc....

Claims

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Application Information

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IPC IPC(8): A61K35/50A61P17/02
CPCA61K35/50
Inventor 杨公明侯银臣吴丽周洁静程永霞
Owner 杨公明
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