A preparation method of composition for treating osteoarthritis
A technology for osteoarthritis and composition, which is applied in the field of composition, can solve the problem that the physiological state of cells cannot be fully realized, and achieve the effect of surface attachment, simple manufacturing process, and promotion of survival
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specific Embodiment approach 1
[0027] Specific embodiment 1: The active ingredients of the composition for treating osteoarthritis of this embodiment include mesenchymal stem cells and cytokines, and the concentration of mesenchymal stem cells of the composition is 5×10 5 ~5×10 7 A / mL, the cytokine is prepared from FGF2-rich plasma and VEGF-rich plasma in a volume ratio of 1:3-10.
[0028] The mesenchymal stem cells may be bone marrow mesenchymal stem cells, adipose mesenchymal stem cells, umbilical cord mesenchymal stem cells, umbilical cord blood mesenchymal stem cells, amniotic membrane mesenchymal stem cells, placental mesenchymal stem cells, or endometrial origin Of mesenchymal stem cells.
[0029] The cytokine-rich plasma can regulate the arthritic microenvironment and reduce pain, and at the same time provide nutrition for the survival of co-transplanted mesenchymal stem cells, promote their effective colonization and survival in the body, and prolong the regeneration and microenvironment of stem cells in ...
specific Embodiment approach 2
[0030] Specific embodiment two: this embodiment is different from specific embodiment one in that the FGF2 concentration in the FGF2-rich plasma is 40-80 pg / mL. Others are the same as the first embodiment.
specific Embodiment approach 3
[0031] Specific embodiment three: This embodiment is different from specific embodiment one or two in that the VEGF concentration in the VEGF-rich plasma is 150-350 pg / mL. Others are the same as the first or second embodiment.
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